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Phenelzine-induced myocardial injury: a case report.
- Source :
-
Journal of medical toxicology : official journal of the American College of Medical Toxicology [J Med Toxicol] 2010 Dec; Vol. 6 (4), pp. 431-4. - Publication Year :
- 2010
-
Abstract
- Introduction: Phenelzine is an irreversible monoamine oxidase inhibitor (MAOI). Hypertensive reactions after ingestion of tyramine-rich foods such as cheese are well known. However, a review of the available medical literature found no previous reports of myocardial infarction resulting from the ingestion of cheese by a patient taking a MAOI.<br />Case Report: A 34-year-old female taking phenelzine for depression developed severe chest pain 1 h after eating cheese. She was hypertensive and the electrocardiography showed ischemic changes in the antero-lateral chest leads. The chest pain and elevated blood pressure were relieved with intravenous morphine and nitroprusside. The initial serum troponin I level was normal, but serial repeat levels showed a rising trend with a peak at 4.89 ug/L (reference range <0.05 ug/L) 6 h after the initial blood draw, suggestive of a non-ST elevation myocardial infarction. The patient subsequently developed hypotension 4 h after another therapeutic dose of phenelzine was served to the patient 4 h after her admission to the ED. This was corrected with at least 2 L of intravenous normal saline boluses. Subsequent EKGs and Sestamibi scan showed no evidence of cardiac ischemia. She was discharged home after a hospital stay of 3 days.<br />Discussion: We believe this to be the first reported case of myocardial infarction resulting from ingestion of cheese in a patient taking a MAOI. It might be expected that hypertensive crisis could lead to a myocardial infarction, but a review of the medical literature found no such cases reported.
- Subjects :
- Adult
Chest Pain drug therapy
Chest Pain etiology
Chest Pain physiopathology
Electrocardiography
Female
Heart drug effects
Heart physiopathology
Humans
Injections, Intravenous
Morphine therapeutic use
Myocardial Infarction blood
Myocardial Infarction physiopathology
Nitroprusside therapeutic use
Treatment Outcome
Troponin I blood
Vasodilator Agents therapeutic use
Cheese adverse effects
Food-Drug Interactions
Monoamine Oxidase Inhibitors adverse effects
Myocardial Infarction chemically induced
Phenelzine adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1937-6995
- Volume :
- 6
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of medical toxicology : official journal of the American College of Medical Toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 20652662
- Full Text :
- https://doi.org/10.1007/s13181-010-0101-y