Monofunctionalization of Calix[4]arene Tetracarboxylic Acid at the Upper Rim with Isothiocyanate Group: First Bifunctional Chelating Agent for Alpha-Emitter Ac-225.

Authors :: Chen X
Ji M
Fisher DR
Wai CM
Source :: Synlett : accounts and rapid communications in synthetic organic chemistry [Synlett] 1999 Sep 01; Vol. 11, pp. 1784-1786.
Publication Year :: 1999
Abstract: A procedure is reported for synthesizing a novel, water-soluble bifunctional chelating agent derived from calix[4]arene. This chelate features tetracarboxylic acid groups at the lower rim as an actinium-225 ionophore, and an isothiocyanate functional group at the upper rim for labeling of the N-terminus of monoclonal antibodies through thiourea linkage.

Language :: English
ISSN :: 0936-5214
Volume :: 11
Database :: MEDLINE
Journal :: Synlett : accounts and rapid communications in synthetic organic chemistry
Publication Type :: Academic Journal
Accession number :: 20651937
Full Text :: https://doi.org/10.1055/s-1999-2944

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