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[Safety analysis of eight patients treated with erlotinib after severe gefitinib-induced liver injury].
- Source :
-
Gan to kagaku ryoho. Cancer & chemotherapy [Gan To Kagaku Ryoho] 2010 Jul; Vol. 37 (7), pp. 1307-11. - Publication Year :
- 2010
-
Abstract
- Gefitinib and erlotinib are commercially available epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) that are widely used for the treatment of non-small-cell lung cancer (NSCLC). Acute severe liver injury, although rare, has been observed in patients receiving these EGFR-TKIs. Some studies have reported that erlotinib treatment does not cause severe liver toxicity in patients with NSCLC who previously presented with severe liver injury during the course of gefitinib treatment. We retrospectively assessed the occurrence of liver toxicity in patients with NSCLC who were receiving erlotinib and had previously presented with severe gefitinib-induced liver injury.Severe liver injury occurred in only 1 of the 8 patients receiving erlotinib treatment. In this case, erlotinib was discontinued because of the onset of grade 3 skin rash and liver injury. After liver function was restored, erlotinib (100 mg) was administered at a lower dose; nonetheless, grade 4 liver injury occurred. Our findings suggest that it is necessary not only to explain the early symptoms of liver toxicity to patients who are receiving erlotinib treatment and have previously experienced gefitinib-induced severe liver injury but also to more closely monitor liver function.
- Subjects :
- Aged
Antineoplastic Agents adverse effects
Chemical and Drug Induced Liver Injury enzymology
Enzyme Inhibitors adverse effects
Erlotinib Hydrochloride
Female
Gefitinib
Humans
Male
Middle Aged
Molecular Structure
Quinazolines chemistry
Antineoplastic Agents therapeutic use
Carcinoma, Non-Small-Cell Lung drug therapy
Chemical and Drug Induced Liver Injury physiopathology
Enzyme Inhibitors therapeutic use
Lung Neoplasms drug therapy
Quinazolines adverse effects
Quinazolines therapeutic use
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0385-0684
- Volume :
- 37
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Gan to kagaku ryoho. Cancer & chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 20647715