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Beneficial effects of social attachment to overcome daily stress.
- Source :
-
Brain research [Brain Res] 2010 Sep 17; Vol. 1352, pp. 43-9. Date of Electronic Publication: 2010 Jul 17. - Publication Year :
- 2010
-
Abstract
- Accumulation of daily life stress (chronic stress) often causes functional gastrointestinal diseases. Central oxytocin plays an important role in attenuating stress responses and regulating positive social interactions. Adult male rats were either paired or singly housed 1 week prior to the stress loading. Solid gastric emptying was measured after 7 consecutive days of chronic heterotypic stress. To study whether endogenous oxytocin is involved in restoring the delayed gastric emptying after paired housing, an oxytocin antagonist was injected intracerebroventricularly (icv) before the gastric emptying study. CRF and oxytocin mRNA expression in the paraventricular nucleus (PVN) and supraoptic nucleus (SON) was evaluated by real time RT-PCR. In singly housed rats, chronic heterotypic stress significantly delayed gastric emptying (35.1+/-2.8%, n=6, P<or=0.01), compared to that of non-stressed rats (53.2+/-1.3%, n=6). Delayed gastric emptying observed in singly housed rats induced by chronic heterotypic stress was significantly improved by paired housing (54.8+/-3.5%, n=8, P<0.05). Central-administration of oxytocin antagonist attenuated the restored gastric emptying in paired housed rats (33.2+/-4.1%, n=6) following chronic heterotypic stress. Increased CRF mRNA expression at the PVN and SON observed in singly housed rats was significantly reduced in paired housed rats following chronic heterotypic stress. In contrast, oxytocin mRNA expression at the PVN and SON was significantly increased in paired housed rats. Social attachment restores delayed gastric emptying following chronic heterotypic stress, via down-regulating CRF expression and up-regulating oxytocin mRNA expression. Our study may provide the scientific benefit of social attachment in our daily life.
- Subjects :
- Animals
Avoidance Learning
Cold Temperature
Corticotropin-Releasing Hormone genetics
DNA Primers
Gastric Emptying drug effects
Gene Expression Regulation
Housing, Animal
Male
Oxytocin antagonists & inhibitors
Oxytocin physiology
Paraventricular Hypothalamic Nucleus physiology
RNA genetics
RNA isolation & purification
RNA, Messenger genetics
Rats
Rats, Sprague-Dawley
Reverse Transcriptase Polymerase Chain Reaction
Supraoptic Nucleus physiology
Swimming
Gastric Emptying physiology
Oxytocin genetics
Restraint, Physical
Social Behavior
Stress, Psychological prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1872-6240
- Volume :
- 1352
- Database :
- MEDLINE
- Journal :
- Brain research
- Publication Type :
- Academic Journal
- Accession number :
- 20643112
- Full Text :
- https://doi.org/10.1016/j.brainres.2010.07.028