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The effect of liposome-delivered prednisolone on collagen density, myofibroblasts, and fibrous capsule thickness around silicone breast implants in rats.
- Source :
-
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society [Wound Repair Regen] 2010 Jul-Aug; Vol. 18 (4), pp. 417-25. - Publication Year :
- 2010
-
Abstract
- Capsular contracture is a potential adverse effect of breast implants. An inflammatory reaction is most likely the origin of fibrosis around the implant. It is possible that some substances may act to prevent this inflammatory reaction. Thus, our goal was to evaluate the effectiveness of local depot prednisolone phosphate-liposomes (PPL) on fibrous capsule formation around textured silicone breast implants. Shell prostheses (2 mL) were implanted in the right (plus PPL group) and left (plus saline solution, saline group) subcutaneous dorsum of 18 rats. In another 18 rats, the implants were positioned in the left of the back without any drug instillation (control group). In the PPL group, the capsule thickness (microm) and density (%) of collagen were significantly (p<0.0001) lower compared with the control group on days 35 and 90 postsurgery. Furthermore, in the PPL group, a significant reduction in myofibroblast count was observed on day 90 postsurgery (p<0.0001). In conclusion, a single dose of depot liposome-delivered prednisolone was effective at impairing capsule formation around the silicone implant. The results suggest a strong local and weak systemic effect of PPL on the fibrous tissue around silicone implants. To our knowledge, no study has yet assessed the effect of PPL on silicone breast implants.
- Subjects :
- Analysis of Variance
Animals
Collagen analysis
Collagen drug effects
Collagen ultrastructure
Colorimetry
Contracture etiology
Contracture pathology
Disease Models, Animal
Drug Evaluation, Preclinical
Fibroblasts drug effects
Fibroblasts ultrastructure
Fibrosis pathology
Foreign-Body Reaction etiology
Foreign-Body Reaction pathology
Glucocorticoids pharmacology
Histological Techniques
Liposomes
Male
Photomicrography
Prednisolone administration & dosage
Prednisolone pharmacology
Rats
Rats, Wistar
Single-Blind Method
Breast Implants adverse effects
Contracture drug therapy
Foreign-Body Reaction drug therapy
Glucocorticoids administration & dosage
Prednisolone analogs & derivatives
Silicones adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1524-475X
- Volume :
- 18
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
- Publication Type :
- Academic Journal
- Accession number :
- 20636553
- Full Text :
- https://doi.org/10.1111/j.1524-475X.2010.00601.x