Back to Search
Start Over
Inhibitors of osteoclastogenesis from Lawsonia inermis leaves.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Aug 15; Vol. 20 (16), pp. 4782-4. Date of Electronic Publication: 2010 Jun 25. - Publication Year :
- 2010
-
Abstract
- Ten phenolic compounds (1-10) were isolated from a methanol extract of Lawsonia inermis leaves including two new ones, lawsoniasides A (1) and B (2). Their structures were elucidated by spectroscopic methods (NMR and FTICRMS) in combination with acid hydrolysis and GC analyses. Compounds 4 and 5 showed a significant inhibition on receptor activator for nuclear factor-kappaB ligand-induced osteoclast formation in murine bone-marrow macrophages.<br /> (2010. Published by Elsevier Ltd.)
- Subjects :
- Animals
Glucosides isolation & purification
Glucosides pharmacology
Macrophages cytology
Macrophages immunology
Magnetic Resonance Spectroscopy
Mice
Molecular Conformation
NF-kappa B metabolism
Phenylpropionates isolation & purification
Phenylpropionates pharmacology
Phloroglucinol chemistry
Phloroglucinol isolation & purification
Phloroglucinol pharmacology
Plant Leaves chemistry
Glucosides chemistry
Lawsonia Plant chemistry
Osteoclasts drug effects
Phenylpropionates chemistry
Phloroglucinol analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 20
- Issue :
- 16
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 20634065
- Full Text :
- https://doi.org/10.1016/j.bmcl.2010.06.118