Back to Search
Start Over
Protection from the 2009 H1N1 pandemic influenza by an antibody from combinatorial survivor-based libraries.
- Source :
-
PLoS pathogens [PLoS Pathog] 2010 Jul 08; Vol. 6 (7), pp. e1000990. Date of Electronic Publication: 2010 Jul 08. - Publication Year :
- 2010
-
Abstract
- Influenza viruses elude immune responses and antiviral chemotherapeutics through genetic drift and reassortment. As a result, the development of new strategies that attack a highly conserved viral function to prevent and/or treat influenza infection is being pursued. Such novel broadly acting antiviral therapies would be less susceptible to virus escape and provide a long lasting solution to the evolving virus challenge. Here we report the in vitro and in vivo activity of a human monoclonal antibody (A06) against two isolates of the 2009 H1N1 pandemic influenza virus. This antibody, which was obtained from a combinatorial library derived from a survivor of highly pathogenic H5N1 infection, neutralizes H5N1, seasonal H1N1 and 2009 "Swine" H1N1 pandemic influenza in vitro with similar potency and is capable of preventing and treating 2009 H1N1 influenza infection in murine models of disease. These results demonstrate broad activity of the A06 antibody and its utility as an anti-influenza treatment option, even against newly evolved influenza strains to which there is limited immunity in the general population.
- Subjects :
- Animals
Antibodies, Monoclonal therapeutic use
Cross Reactions immunology
Disease Models, Animal
Disease Outbreaks
Humans
Influenza A Virus, H5N1 Subtype immunology
Influenza, Human prevention & control
Mice
Orthomyxoviridae Infections prevention & control
Survivors
Antibodies, Viral therapeutic use
Immunotherapy methods
Influenza A Virus, H1N1 Subtype immunology
Influenza, Human drug therapy
Orthomyxoviridae Infections drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1553-7374
- Volume :
- 6
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- PLoS pathogens
- Publication Type :
- Academic Journal
- Accession number :
- 20628565
- Full Text :
- https://doi.org/10.1371/journal.ppat.1000990