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Neurochemical measures co-vary with personality traits: forensic psychiatric findings replicated in a general population sample.
- Source :
-
Psychiatry research [Psychiatry Res] 2010 Aug 15; Vol. 178 (3), pp. 525-30. Date of Electronic Publication: 2010 Jul 08. - Publication Year :
- 2010
-
Abstract
- Neurobiological markers in cerebrospinal fluid (CSF) and in serum, previously found to co-vary with destructive personality traits in violent offenders, were explored in a general population sample of 21 patients undergoing knee surgery. Results on the Karolinska Scales of Personality (KSP) and the Temperament and Character Inventory (TCI) were compared with CSF/serum albumin ratios and serum concentrations of beta-trace protein (betaTP) (as markers for blood-brain barrier (BBB) permeability), to CSF/serum albumin ratios between the dopamine and serotonin metabolites homovanillic acid (HVA)/5-hydroxyindoleacetic acid (HIAA) and to CSF and serum ratios between activated thyroid hormone (T3) and its precursor T4. Serum betaTP concentrations correlated with CSF/serum albumin ratios (P=0.018), but not with preoperative serum creatinine concentrations. Serum betaTP correlated significantly with Monotony Avoidance and Impulsiveness; CSF HVA/5-HIAA ratios with Irritability and low Cooperativeness. The betaTP is a potential serum marker for the integrity of the BBB that does not necessitate lumbar puncture. Thyroid hormones did not correlate with personality traits. As reported in forensic psychiatric patients, aggressive, unempathic personality traits were thus associated with increased dopaminergic activity in relation to the serotonergic activity and impulsivity to increased BBB permeability also in a general population group.<br /> (Copyright (c) 2010 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Community Health Planning
Creatinine blood
Creatinine cerebrospinal fluid
Female
Homovanillic Acid blood
Homovanillic Acid cerebrospinal fluid
Humans
Hydroxyindoleacetic Acid blood
Hydroxyindoleacetic Acid cerebrospinal fluid
Intramolecular Oxidoreductases blood
Intramolecular Oxidoreductases cerebrospinal fluid
Knee surgery
Lipocalins blood
Lipocalins cerebrospinal fluid
Male
Middle Aged
Personality Inventory
Serum Albumin metabolism
Thyroid Hormones cerebrospinal fluid
Forensic Psychiatry
Neurochemistry
Personality
Subjects
Details
- Language :
- English
- ISSN :
- 0165-1781
- Volume :
- 178
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Psychiatry research
- Publication Type :
- Academic Journal
- Accession number :
- 20619466
- Full Text :
- https://doi.org/10.1016/j.psychres.2010.05.016