Back to Search
Start Over
Hepatitis C virus infection is associated with endothelial dysfunction in HIV/hepatitis C virus coinfected patients.
- Source :
-
AIDS (London, England) [AIDS] 2010 Aug 24; Vol. 24 (13), pp. 2059-67. - Publication Year :
- 2010
-
Abstract
- Objective: To quantify serum levels of intercellular adhesion molecule-1 (sICAM-1) and vascular cell adhesion molecule-1 (sVCAM-1) in HIV/HCV coinfected patients to examine their association with several clinical and epidemiological characteristics and the therapeutic responsiveness to interferon (IFN)-alpha and ribavirin therapy (IFN-alpha + RBV).<br />Design: Retrospective study.<br />Methods: We carried out a cross-sectional study with 183 IFN-alpha-naive patients on HAART, and 24 healthy controls. We also analyzed 30 out of 183 patients on IFN-alpha + RBV for the duration of 48 weeks.<br />Results: HIV/HCV coinfected patients had higher levels of sICAM-1 and sVCAM-1 than the healthy control group (P < 0.05). Patients with HCV-genotype 1, advanced fibrosis (F>or=3) or moderate to severe activity grade (A>or=2) had the highest values of sICAM-1 and sVCAM-1. When we carried out a multivariate analysis, we found a significant positive relationship between both HCV-genotype 1 and advanced fibrosis (F>or=3) with sICAM-1 (R = 0.549; P < 0.001); and a significant positive relationship between HCV-genotype 1 and advanced fibrosis (F>or=3) with sVCAM-1 (R = 0.624; P < 0.001). We also found a positive relationship of sICAM-1 or sVCAM-1 levels with transaminases and alkaline phosphatase circulation levels (P < 0.05). Nonresponder patients had higher sICAM-1 and sVCAM-1 serum levels, and patients with sustained virologic response had significantly lower levels of sICAM-1 (P = 0.001) and sVCAM-1 (P = 0.019).<br />Conclusion: HIV and HCV coinfection induces alterations in sICAM-1 and sVCAM-1 serum levels, which were higher in patients with HCV-genotype 1 and advanced stage of HCV infection. However, response to IFN-alpha + RBV may reduce these cardiovascular risk markers.
- Subjects :
- Adult
Biomarkers blood
Cardiovascular Diseases etiology
Cardiovascular Diseases virology
Cross-Sectional Studies
Female
HIV Infections complications
HIV Infections virology
Hepatitis C immunology
Hepatitis C virology
Humans
Male
Retrospective Studies
Viral Load
Antiretroviral Therapy, Highly Active adverse effects
Cardiovascular Diseases chemically induced
HIV Infections drug therapy
Hepacivirus physiology
Hepatitis C drug therapy
Intercellular Adhesion Molecule-1 blood
Vascular Cell Adhesion Molecule-1 blood
Subjects
Details
- Language :
- English
- ISSN :
- 1473-5571
- Volume :
- 24
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- AIDS (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 20616694
- Full Text :
- https://doi.org/10.1097/QAD.0b013e32833ce54d