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Exaggerated liver injury induced by renal ischemia reperfusion in diabetes: effect of exenatide.
- Source :
-
Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association [Saudi J Gastroenterol] 2010 Jul-Sep; Vol. 16 (3), pp. 174-80. - Publication Year :
- 2010
-
Abstract
- Background/aim: This study was designed to investigate the possible effect of exenatide (Glucagon like Peptide-1 receptor agonist) on liver injury (distant organ) induced by renal ischemia reperfusion (IR) in diabetic rats.<br />Materials and Methods: In vivo renal IR was performed in both type 2 diabetic and normal rats. Each protocol comprised ischemia for 30 minutes followed by reperfusion for 24 hours and a treatment period of 14 days before induction of ischemia.<br />Results: Lipid peroxidation, xanthine oxidase activity, myeloperoxidase activity and nitric oxide level in liver tissue were significantly increased (P < 0.01, P < 0.001, P < 0.001, P < 0.05, respectively), after IR in diabetic rats compared to normal rats. Antioxidant enzymes like glutathione, superoxide dismutase, catalase and glutathione peroxidase were significantly reduced (P < 0.05, P < 0.05, P < 0.01, P < 0.05, respectively), after IR in diabetic rats compared to normal rats. Exenatide treatment significantly normalized (P < 0.01), these biochemical parameters in treated rats compared to diabetic IR rats. Serum creatinine phosphokinase activity and liver function enzymes were also significantly normalized (P < 0.001, P < 0.001, respectively), after administration of exenatide.<br />Conclusion: Exenatide exerted protective effect on exaggerated remote organ (liver) injury induced by renal IR in diabetes.
- Subjects :
- Animals
Catalase metabolism
Creatine Kinase metabolism
Diabetes Mellitus, Experimental enzymology
Exenatide
Glutathione metabolism
Glutathione Peroxidase metabolism
Kidney drug effects
Kidney enzymology
Kidney Diseases enzymology
Kidney Diseases etiology
Lipid Peroxidation
Liver drug effects
Liver enzymology
Liver Diseases enzymology
Liver Diseases etiology
Liver Function Tests
Nitric Oxide metabolism
Rats
Rats, Wistar
Reperfusion Injury etiology
Superoxide Dismutase metabolism
Treatment Outcome
Xanthine Oxidase metabolism
Diabetes Mellitus, Experimental drug therapy
Kidney blood supply
Kidney Diseases drug therapy
Liver blood supply
Liver Diseases drug therapy
Peptides pharmacology
Reperfusion Injury drug therapy
Venoms pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1998-4049
- Volume :
- 16
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
- Publication Type :
- Academic Journal
- Accession number :
- 20616412
- Full Text :
- https://doi.org/10.4103/1319-3767.65187