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Relationship between let-7a and gastric mucosa cancerization and its significance.
- Source :
-
World journal of gastroenterology [World J Gastroenterol] 2010 Jul 14; Vol. 16 (26), pp. 3325-9. - Publication Year :
- 2010
-
Abstract
- Aim: To investigate let-7a expression and analyze the correlation between let-7a and progression of gastric mucosa cancerization.<br />Methods: The tissue microarray was constructed previously in 52 cases of human gastric carcinoma, 17 cases of chronic atrophic gastritis (atypical hyperplasia) and 11 cases of normal gastric tissue, and tissue microarrays combined with in situ hybridization were used to detect the expression of let-7a.<br />Results: The positive rates of let-7a in normal gastric tissue, chronic atrophic gastritis and gastric carcinoma were 90.9%, 88.2% and 86.5%, respectively, without significant differences among the groups (P > 0.05). However, an intense signal of let-7a was observed in gastric epithelial cells, whereas a less intense signal was found in gastric atypical hyperplasia epithelial cells and a weak signal in gastric carcinoma epithelial cells. The expression of let-7a decreased along with the progression of gastric mucosa cancerization (P < 0.05). In the group of gastric carcinoma, the expression of let-7a was even significantly lower in gastric carcinomas with lymph node metastasis than in those without metastasis (P < 0.05).<br />Conclusion: Gastric carcinoma has relatively lower expression of let-7a. Reduced let-7a may be a fundamental factor in the formation and lymph node metastasis of gastric carcinoma.
- Subjects :
- Case-Control Studies
Gastric Mucosa metabolism
Gastritis, Atrophic genetics
Gastritis, Atrophic metabolism
Humans
In Situ Hybridization
Lymphatic Metastasis genetics
Tissue Array Analysis
MicroRNAs genetics
MicroRNAs metabolism
RNA, Neoplasm genetics
RNA, Neoplasm metabolism
Stomach Neoplasms genetics
Stomach Neoplasms metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2219-2840
- Volume :
- 16
- Issue :
- 26
- Database :
- MEDLINE
- Journal :
- World journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 20614490
- Full Text :
- https://doi.org/10.3748/wjg.v16.i26.3325