Back to Search
Start Over
Inflammatory cytokines and aromatase inhibitor-associated musculoskeletal syndrome: a case-control study.
- Source :
-
British journal of cancer [Br J Cancer] 2010 Jul 27; Vol. 103 (3), pp. 291-6. Date of Electronic Publication: 2010 Jul 06. - Publication Year :
- 2010
-
Abstract
- Background: The aromatase inhibitor (AI)-associated musculoskeletal syndrome (AIMSS) occurs in approximately 50% of AI-treated patients. Inflammatory mediators are associated with oestrogen signalling and may change with oestrogen depletion. We hypothesised that AIMSS may be associated with changes in circulating inflammatory markers.<br />Methods: Patients with breast cancer were enrolled in a trial of adjuvant AI therapy. Changes in pain and function during therapy were assessed prospectively. We selected 30 cases with AIMSS and 22 controls without AIMSS, matched for demographics and prior therapy. Serum samples collected at baseline and during treatment were assayed for multiple inflammatory cytokines and lipid mediators using multiplex assays.<br />Results: Before AI therapy, mean serum concentrations of 6 of 36 assayed factors were statistically significantly lower in cases than controls (all P<0.003). No statistically significant changes during AI therapy relative to pre-treatment were observed between cases and controls for any of the inflammatory markers tested.<br />Conclusion: AIMSS is probably not associated with a systemic inflammatory response. Pre-treatment cytokine levels may predict for development of AIMSS.
- Subjects :
- Aged
Antineoplastic Agents therapeutic use
Aromatase Inhibitors adverse effects
Breast Neoplasms blood
Bridged-Ring Compounds therapeutic use
Case-Control Studies
Estrogens deficiency
Female
Humans
Middle Aged
Postmenopause
Syndrome
Tamoxifen therapeutic use
Taxoids therapeutic use
Androstadienes therapeutic use
Aromatase Inhibitors therapeutic use
Breast Neoplasms drug therapy
Cytokines blood
Inflammation chemically induced
Musculoskeletal Diseases chemically induced
Subjects
Details
- Language :
- English
- ISSN :
- 1532-1827
- Volume :
- 103
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- British journal of cancer
- Publication Type :
- Academic Journal
- Accession number :
- 20606683
- Full Text :
- https://doi.org/10.1038/sj.bjc.6605768