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Evaluation of light/dark cycle in anxiety- and depressive-like behaviors after regular treatment with methylphenidate hydrochloride in rats of different ages.
- Source :
-
Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) [Braz J Psychiatry] 2011 Mar; Vol. 33 (1), pp. 55-8. Date of Electronic Publication: 2010 Jul 02. - Publication Year :
- 2011
-
Abstract
- Objective: Methylphenidate hydrochloride is the most widely used medication for treatment and management of attention-deficit hyperactivity disorder. However, the chronic effects of methylphenidate hydrochloride on anxiety- and depressive-like rat behaviors remain poorly investigated. In this context, the present study evaluated the effects of treatment with methylphenidate hydrochloride on anxiety- and depressive-like behaviors using young and adult rats during the light and the dark cycle.<br />Method: Male Wistar rats (25 or 60 days old) received a once-daily (in either the light or dark cycle) methylphenidate hydrochloride (2mg/kg) or saline intraperitoneal injection for 28 days. We performed elevated plus maze and forced swimming test two hours after the last injection.<br />Results: The light/dark cycle was a significant factor in the anxiety-like behaviors; however, no significant interaction between all three factors (cycle, age and methylphenidate hydrochloride) was found. Nevertheless, we observed a nominally significant interaction between the light/ dark cycle and age in the forced swimming test.<br />Conclusion: Our results have shown that age and the light/dark cycle are more significant modulators of anxiety- and depressive-like behaviors than methylphenidate hydrochloride treatment.
- Subjects :
- Age Factors
Animals
Anxiety Disorders psychology
Attention Deficit Disorder with Hyperactivity drug therapy
Depressive Disorder psychology
Male
Rats
Rats, Wistar
Anti-Anxiety Agents therapeutic use
Antidepressive Agents therapeutic use
Anxiety Disorders drug therapy
Depressive Disorder drug therapy
Methylphenidate therapeutic use
Photoperiod
Subjects
Details
- Language :
- English
- ISSN :
- 1809-452X
- Volume :
- 33
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)
- Publication Type :
- Academic Journal
- Accession number :
- 20602012
- Full Text :
- https://doi.org/10.1590/s1516-44462010005000018