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Molecular mechanisms of host cell invasion by Trypanosoma cruzi.
- Source :
-
Experimental parasitology [Exp Parasitol] 2010 Nov; Vol. 126 (3), pp. 283-91. Date of Electronic Publication: 2010 Jun 18. - Publication Year :
- 2010
-
Abstract
- The protozoan parasite Trypanosoma cruzi, the etiologic agent of Chagas disease, is an obligate intracellular protozoan pathogen. Overlapping mechanisms ensure successful infection, yet the relationship between these cellular events and clinical disease remains obscure. This review explores the process of cell invasion from the perspective of cell surface interactions, intracellular signaling, modulation of the host cytoskeleton and endosomal compartment, and the intracellular innate immune response to infection.<br /> ((c) 2010 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Calcium metabolism
Cell Membrane parasitology
Chagas Disease immunology
Chagas Disease pathology
Cytoplasm parasitology
Cytoskeleton parasitology
Extracellular Matrix parasitology
Host-Parasite Interactions
Humans
Insect Vectors parasitology
Membrane Glycoproteins metabolism
Protozoan Proteins metabolism
Receptors, Cell Surface metabolism
Signal Transduction physiology
Chagas Disease parasitology
Trypanosoma cruzi physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2449
- Volume :
- 126
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Experimental parasitology
- Publication Type :
- Academic Journal
- Accession number :
- 20599990
- Full Text :
- https://doi.org/10.1016/j.exppara.2010.06.023