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Baccoside A suppresses epileptic-like seizure/convulsion in Caenorhabditis elegans.
- Source :
-
Seizure [Seizure] 2010 Sep; Vol. 19 (7), pp. 439-42. Date of Electronic Publication: 2010 Jul 03. - Publication Year :
- 2010
-
Abstract
- The 1 mm long Caenorhabditis elegans is one of the prime research tools to study different human neurodegenerative diseases. We have considered the case in which increase in the surrounding temperature of this multicellular model leads to abnormal bursts of neuronal cells that can be linked to seizure or convulsion. The induction of such seizure/convulsion mechanism was done by gradually increasing the temperature with 1x buffer (100 mM NaCl, 50 mM MgCl(2)) in adult C. elegans. In the present experiment it is demonstrated that Baccoside A can significantly reduce the seizure/convulsion in C. elegans at higher temperatures (26-28+/-1 degrees C). Furthermore, in T-type Ca(2+) channel cca-1 mutant worms, no convulsion was recorded. Our experimental results suggest that plant molecules from Bacopa monnieri may be useful in suppressing the seizure/convulsion in worms.<br /> (2010 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Caenorhabditis elegans physiology
Disease Models, Animal
Epilepsy drug therapy
Hot Temperature
Saponins pharmacology
Seizures drug therapy
Triterpenes pharmacology
Bacopa chemistry
Caenorhabditis elegans drug effects
Neurons drug effects
Phytotherapy methods
Plant Extracts pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1532-2688
- Volume :
- 19
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Seizure
- Publication Type :
- Academic Journal
- Accession number :
- 20598917
- Full Text :
- https://doi.org/10.1016/j.seizure.2010.06.005