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Stable seroepidemiology of hepatitis B after universal immunization in Taiwan: A 3-year study of national surveillance of primary school students.
- Source :
-
Vaccine [Vaccine] 2010 Aug 02; Vol. 28 (34), pp. 5605-8. Date of Electronic Publication: 2010 Jun 21. - Publication Year :
- 2010
-
Abstract
- Background: This study is aimed to investigate if there was increased risk of HBV acquisition among first graders in Taiwan during a 3-year follow-up period.<br />Methods: A total of 1545 healthy first graders, who were vaccinated against HBV in infancy, were recruited in 2005. All subjects were checked for hepatitis B surface antigens (HBsAg), antibodies to HBsAg (anti-HBs), and to the hepatitis B core antigen (anti-HBc). Nucleotide sequence of the "a" determinant of HBsAg was determined by polymerase chain reaction and direct sequencing in the HBsAg carriers.<br />Results: Among 1545 subjects, 0.78% were HBsAg seropositive, 54.30% were anti-HBs seropositive, and 1.68% anti-HBc seropositive. Three of the 10 HBV carriers (30%), whose HBV DNA were sequenced for the S gene, had surface antigen mutants at the "a" determinant.<br />Conclusion: There were no new chronic HBV infections in this cohort of children for two consecutive years. HBV S gene vaccine escape mutants did exist in the vaccine-failure population, but they may not have made a major health impact.<br /> (Copyright 2010 Elsevier Ltd. All rights reserved.)
- Subjects :
- Carrier State epidemiology
Child
DNA, Viral analysis
Female
Hepatitis B genetics
Hepatitis B Antibodies blood
Hepatitis B Core Antigens blood
Hepatitis B Surface Antigens blood
Humans
Male
Seroepidemiologic Studies
Taiwan epidemiology
Hepatitis B epidemiology
Hepatitis B Vaccines administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2518
- Volume :
- 28
- Issue :
- 34
- Database :
- MEDLINE
- Journal :
- Vaccine
- Publication Type :
- Academic Journal
- Accession number :
- 20598405
- Full Text :
- https://doi.org/10.1016/j.vaccine.2010.06.029