Back to Search
Start Over
Licorice-induced hypertension and common variants of genes regulating renal sodium reabsorption.
- Source :
-
Annals of medicine [Ann Med] 2010 Sep; Vol. 42 (6), pp. 465-74. - Publication Year :
- 2010
-
Abstract
- Aim: To study if gene alterations affecting renal sodium reabsorption associate with susceptibility to licorice-induced hypertension.<br />Methods: Finnish subjects (n = 30) with a previously documented incident of licorice-induced hypertension were recruited for the study using a newspaper announcement. Their previous clinical and family histories as well as serum electrolyte levels were examined. DNA samples from all individuals were screened for variants of the genes encoding 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2) and alpha-, beta-, and gamma-subunits of the epithelial sodium channel (ENaC).<br />Results: Upon licorice predisposition, the patients had a mean blood pressure of 201/118 mmHg. Circulating potassium, renin, and aldosterone levels were low. No significant DNA variations were identified in the 11betaHSD2 gene. Four subjects were heterozygous for beta- and gammaENaC variants previously shown to be associated with hypertension. Furthermore, a novel G insertion (2004-2005insG) in the SCNN1A gene encoding the alphaENaC was identified in two subjects. The frequency of these ENaC variants was significantly higher in subjects with licorice-induced hypertension (6/30 i.e. 20%) than in blood donors (11/301 i.e. 3.7%, P = 0.002).<br />Conclusions: Defects of the 11betaHSD2 gene do not constitute a likely cause for licorice-induced hypertension. Variants of the ENaC subunits may render some individuals sensitive to licorice-induced metabolic alterations and hypertension.
- Subjects :
- Adolescent
Adult
Aldosterone blood
Female
Genetic Variation
Humans
Hypertension blood
Hypertension genetics
Kidney metabolism
Male
Middle Aged
Mineralocorticoid Excess Syndrome, Apparent blood
Mineralocorticoid Excess Syndrome, Apparent genetics
Mutagenesis, Insertional
Potassium blood
Renin blood
Sodium metabolism
Young Adult
11-beta-Hydroxysteroid Dehydrogenase Type 2 genetics
Epithelial Sodium Channels genetics
Glycyrrhiza adverse effects
Hypertension chemically induced
Mineralocorticoid Excess Syndrome, Apparent chemically induced
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2060
- Volume :
- 42
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Annals of medicine
- Publication Type :
- Academic Journal
- Accession number :
- 20597806
- Full Text :
- https://doi.org/10.3109/07853890.2010.499133