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Dynamic covalent chemistry in aid of peptide self-assembly.
- Source :
-
Current opinion in biotechnology [Curr Opin Biotechnol] 2010 Aug; Vol. 21 (4), pp. 401-11. Date of Electronic Publication: 2010 Jun 30. - Publication Year :
- 2010
-
Abstract
- Self-assembled peptide systems have been widely studied in the context of gaining understanding of the rules that govern biomolecular processes and increasingly as new bio-inspired nanomaterials. Such materials may be designed to be highly dynamic, displaying adaptive and self-healing properties. This review focuses on recent approaches, which exploit reversible covalent and noncovalent chemistry in combination with peptide-based self-assembly. Selected examples of recent advances include sulphur and nitrogen-based reversible reactions, metal-ligand coordination and enzyme-assisted transamidation that lead to structures such as catenanes, nanofibres, β-hairpins and coiled-coil assemblies. It is demonstrated that these structures give rise to nanomaterials with emergent properties that are highly sensitive and adaptive to external conditions and may allow for in vitro evolution of novel peptide nanostructures via templating or self-recognition.<br /> (Copyright © 2010 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1879-0429
- Volume :
- 21
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Current opinion in biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 20594820
- Full Text :
- https://doi.org/10.1016/j.copbio.2010.05.010