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Osteopontin (OPN) expression in thyroid carcinoma.
- Source :
-
Anticancer research [Anticancer Res] 2010 May; Vol. 30 (5), pp. 1681-8. - Publication Year :
- 2010
-
Abstract
- Background: Osteopontin (OPN) and its interacting partner CEA-cell adhesion molecule (CEACAM1) mediate similar biological functions and have been expressed in several types of cancer. Here we investigated the prognostic significance of OPN in thyroid tumours and correlated our findings with the expression of CEACAM1.<br />Materials and Methods: 297 human thyroid samples were collected in a tissue microarray and as fresh frozen samples to perform immunohistochemistry and western blotting for OPN and to compare these data with our previously published data on CEACAM1 expression.<br />Results: Nearly all normal samples were negative for OPN. Some thyroid adenomas were weakly OPN positive whereas many carcinomas were strongly positive. In contrast to CEACAM1, which was preferentially expressed in metastatic papillary carcinomas, no associations were found between OPN expression and patient age, gender and tumour size.<br />Conclusion: These results may have future implications for the diagnosis and management of patients with thyroid cancers.
- Subjects :
- Antigens, CD biosynthesis
Carcinoembryonic Antigen biosynthesis
Cell Adhesion Molecules biosynthesis
Female
Humans
Immunohistochemistry methods
Male
Models, Statistical
Neoplasm Metastasis
Thyroid Gland metabolism
Carcinoma metabolism
Gene Expression Regulation
Gene Expression Regulation, Neoplastic
Osteopontin biosynthesis
Thyroid Neoplasms metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1791-7530
- Volume :
- 30
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 20592361