[Metabotropic glutamate receptors in the mechanisms of plasticity of central nervous system of the honeybee Apis mellifera].

Localization of metabotropic glutamate receptors (MGR) in head ganglion of honeybee Apis mellifera, and mechanisms of participation of activated MGR in CNS plasticity are investigated by means of complex approach using immunochemical, electrophysiological and behavioral methods. Influense of MGR activation on GABAergic system and ionotropic glutamate receptors (IGR) of AMPA- and NMDA-subtypes in studied. MGRa are revealed in lateral and medial calices of mushroom bodies. The inhibiting influence of MGR on AMPA- and NMDA receptors is shown using method of conditioned reflex. Previous activation of MGR neutralizes the inhibiting effect of GABA. Modulating role of heterogeneous MGR population in mechanisms of CNS plasticity on the level of glutamate-ergic synapse, and at interaction with GABAergic system is discussed.