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Protein kinase D as a potential new target for cancer therapy.
- Source :
-
Biochimica et biophysica acta [Biochim Biophys Acta] 2010 Dec; Vol. 1806 (2), pp. 183-92. Date of Electronic Publication: 2010 May 24. - Publication Year :
- 2010
-
Abstract
- Protein kinase D is a novel family of serine/threonine kinases and diacylglycerol receptors that belongs to the calcium/calmodulin-dependent kinase superfamily. Evidence has established that specific PKD isoforms are dysregulated in several cancer types, and PKD involvement has been documented in a variety of cellular processes important to cancer development, including cell growth, apoptosis, motility, and angiogenesis. In light of this, there has been a recent surge in the development of novel chemical inhibitors of PKD. This review focuses on the potential of PKD as a chemotherapeutic target in cancer treatment and highlights important recent advances in the development of PKD inhibitors.<br /> (Copyright © 2010 Elsevier B.V. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 0006-3002
- Volume :
- 1806
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Biochimica et biophysica acta
- Publication Type :
- Academic Journal
- Accession number :
- 20580776
- Full Text :
- https://doi.org/10.1016/j.bbcan.2010.05.003