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Environmental exposures and autoimmune thyroid disease.
- Source :
-
Thyroid : official journal of the American Thyroid Association [Thyroid] 2010 Jul; Vol. 20 (7), pp. 755-61. - Publication Year :
- 2010
-
Abstract
- Background: Environmental exposures, ranging from perchlorate in rocket fuel to polychlorinated biphenols, have been shown to influence thyroid function. Although most of these agents are associated with reduced thyroid hormone levels or impaired thyroid hormone action, a number of environmental exposures confer an increased risk of autoimmune thyroid disease.<br />Summary: Factors that increase autoimmune thyroid disease risk include radiation exposure, both from nuclear fallout and medical radiation, increased iodine intake, as well as several contaminants in the environment that influence the thyroid. Although approximately 70% of the risk for developing autoimmune thyroid disease is attributable to genetic background, environmental triggers are thought to play a role in the development of autoimmune thyroid disease in susceptible individuals.<br />Conclusions: Understanding the association of environmental agents with thyroid dysfunction can be utilized to reduce the risk to populations. Knowledge of the specific factors that trigger autoimmune thyroid disease and their mode of action, however, may also inform risk reduction in the individual patient. These factors are especially relevant for those at increased risk of autoimmune thyroid disease based on family history.
- Subjects :
- Animals
Autoimmune Diseases chemically induced
Autoimmune Diseases genetics
Autoimmune Diseases prevention & control
Genetic Predisposition to Disease
Humans
Incidence
Iodine administration & dosage
Iodine deficiency
Iodine metabolism
Iodine poisoning
Risk Reduction Behavior
Thyroid Diseases chemically induced
Thyroid Diseases genetics
Thyroid Diseases prevention & control
Thyroid Gland drug effects
Thyroid Gland radiation effects
Autoimmune Diseases epidemiology
Environmental Exposure adverse effects
Thyroid Diseases epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1557-9077
- Volume :
- 20
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Thyroid : official journal of the American Thyroid Association
- Publication Type :
- Academic Journal
- Accession number :
- 20578899
- Full Text :
- https://doi.org/10.1089/thy.2010.1636