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Antihypertensive effect of the oral angiotensin converting-enzyme inhibitor SQ 14225 in man.
- Source :
-
The New England journal of medicine [N Engl J Med] 1978 May 04; Vol. 298 (18), pp. 991-5. - Publication Year :
- 1978
-
Abstract
- We investigated the antihypertensive effect of the angiotensin converting-enzyme inhibitor SQ 14225 in 12 hypertensive patients for periods of three to 24 weeks. Blood pressure decreased in all patients (from 177 +/- 8/110 +/- 2 to 136 +/- 6/88 +/- 2 mm Hg--mean +/- S.E.); oral doses ranged from 400 to 1000 mg daily. Concomitant effects noted were small increases in plasma potassium concentration and pulse rate. One patient experienced a transient febrile reaction. Plasma renin activity rose during treatment, plasma aldosterone decreased, and angiotensin-converting-enzyme activity was virtually eliminated. There was no significant correlation between pretreatment plasma renin activity and degree of blood-pressure fall with SQ 14225. The exact mechanisms contributing to the blood-pressure-lowering effect of this agent remain unclear. SQ 14225 is a promising new antihypertensive agent, effective in patients refractory to traditional medical therapy.
- Subjects :
- Administration, Oral
Adult
Aged
Antihypertensive Agents therapeutic use
Drug Evaluation
Female
Humans
Hypertension blood
Hypertension drug therapy
Hypertension, Renal drug therapy
Male
Middle Aged
Proline administration & dosage
Proline therapeutic use
Renin blood
Angiotensin-Converting Enzyme Inhibitors
Antihypertensive Agents administration & dosage
Proline analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 0028-4793
- Volume :
- 298
- Issue :
- 18
- Database :
- MEDLINE
- Journal :
- The New England journal of medicine
- Publication Type :
- Academic Journal
- Accession number :
- 205788
- Full Text :
- https://doi.org/10.1056/NEJM197805042981803