Combination of cytomegalovirus enhancer with human cellular promoters for gene-induced chondrogenesis of human bone marrow mesenchymal stem cells.

Authors :: Iwai R
Kumagai Y
Fujiwara M
Wakitani S
Takagi M
Source :: Journal of bioscience and bioengineering [J Biosci Bioeng] 2010 Nov; Vol. 110 (5), pp. 593-6. Date of Electronic Publication: 2010 Jun 23.
Publication Year :: 2010
Abstract: High-expression plasmid vectors for human mesenchymal stem cells (MSCs) were constructed by combination of cytomegalovirus immediate-early enhancer with cellular promoters. MSCs transfected with the vector showed higher transgene production of a cytokine, which increased the differentiation level to chondrocytes.<br /> (Copyright © 2010 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.)

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