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Combination of cytomegalovirus enhancer with human cellular promoters for gene-induced chondrogenesis of human bone marrow mesenchymal stem cells.
- Source :
-
Journal of bioscience and bioengineering [J Biosci Bioeng] 2010 Nov; Vol. 110 (5), pp. 593-6. Date of Electronic Publication: 2010 Jun 23. - Publication Year :
- 2010
-
Abstract
- High-expression plasmid vectors for human mesenchymal stem cells (MSCs) were constructed by combination of cytomegalovirus immediate-early enhancer with cellular promoters. MSCs transfected with the vector showed higher transgene production of a cytokine, which increased the differentiation level to chondrocytes.<br /> (Copyright © 2010 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Base Sequence
Chondrogenesis physiology
Collagen genetics
Collagen Type I
DNA Primers genetics
Enhancer Elements, Genetic
Genes, Immediate-Early
Genetic Engineering
Genetic Vectors
Humans
Mesenchymal Stem Cells metabolism
Promoter Regions, Genetic
Recombinant Proteins biosynthesis
Recombinant Proteins genetics
Transfection
Transforming Growth Factor beta3 biosynthesis
Transforming Growth Factor beta3 genetics
Chondrogenesis genetics
Cytomegalovirus genetics
Mesenchymal Stem Cells cytology
Subjects
Details
- Language :
- English
- ISSN :
- 1347-4421
- Volume :
- 110
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of bioscience and bioengineering
- Publication Type :
- Academic Journal
- Accession number :
- 20576467
- Full Text :
- https://doi.org/10.1016/j.jbiosc.2010.05.015