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Accuracy of FDG-PET-CT in the diagnostic work-up of vascular prosthetic graft infection.

Authors :
Bruggink JL
Glaudemans AW
Saleem BR
Meerwaldt R
Alkefaji H
Prins TR
Slart RH
Zeebregts CJ
Source :
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery [Eur J Vasc Endovasc Surg] 2010 Sep; Vol. 40 (3), pp. 348-54. Date of Electronic Publication: 2010 Jun 23.
Publication Year :
2010

Abstract

Objectives: To investigate the diagnostic accuracy of fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) compared with computed tomography (CT) scanning and added value of fused FDG-PET-CT in diagnosing vascular prosthetic graft infection.<br />Design: Prospective cohort study with retrospective analysis.<br />Materials: Twenty five patients with clinically suspected vascular prosthetic infection underwent CT and FDG-PET scanning.<br />Methods: Two nuclear medicine physicians assessed the FDG-PET scans; all CT scans were assessed by two radiologists. Fused FDG-PET/CT were judged by the radiologist and the nuclear medicine physician. The concordance between CT and FDG-PET and the inter-observer agreement between the different readers were investigated.<br />Results: Fifteen patients had a proven infection by culture. Single FDG-PET had the best results (sensitivity 93%, specificity 70%, positive predictive value 82% and negative predictive value 88%). For CT, these values were 56%, 57%, 60% and 58%, respectively. Fused CT and FDG-PET imaging also showed high sensitivity and specificity rates and high positive and negative values. Inter-observer agreement for FDG-PET analysis was excellent (kappa = 1.00) and moderate for CT and fused FDG-PET-CT analysis (0.63 and 0.66, respectively).<br />Conclusion: FDG-PET scanning showed a better diagnostic accuracy than CT for the detection of vascular prosthetic infection. This study suggests that FDG-PET provides a useful tool in the work-up for diagnosis of vascular prosthetic graft infection.<br /> (Copyright 2010 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1532-2165
Volume :
40
Issue :
3
Database :
MEDLINE
Journal :
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery
Publication Type :
Academic Journal
Accession number :
20576451
Full Text :
https://doi.org/10.1016/j.ejvs.2010.05.016