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[Studies on chemistry component and the biological activity of petroleum ether extraction from pre-and post-processed of Cornus officinalis].
- Source :
-
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials [Zhong Yao Cai] 2010 Feb; Vol. 33 (2), pp. 192-5. - Publication Year :
- 2010
-
Abstract
- Objective: To investigate substance basis for improving pharmacodynamics by comparing the chemical constituents of petroleum ether extraction from crude and processed Cornus officinalis and the effects on the immunologic function of mice with immunosuppression induced.<br />Methods: The volatile components in petroleum ether extraction were analyses by GC-MS. Non-specific immune function was determined by cleaning carbon particle index K, Swallow index a, spleen index and thymus index. The specific humoral immune function was evaluated by detecting the content of serum hemolysin.<br />Results: The chemical constituents of petroleum ether extraction of Cornus officinalis before and after being processed had significant changes. After being processed, Vitamin E increased by 46.6%, linoleic acid increased by 18.3% and methyl linen increased by 30.9%. The extraction increased clearance rate of charcoal carbon particles index K, swallow index alpha, spleen index, thymus index and the level of serum hemolysin.<br />Conclusion: The extraction can markedly improve non-specific immune function and the specific humoral immune function which are active sites of improving immunologic function and post-processed is better. Substance basis could be Vitamin E, Linoleic acid, methyl linen and so on.
- Subjects :
- Animals
Cyclophosphamide adverse effects
Disease Models, Animal
Female
Gas Chromatography-Mass Spectrometry
Hemolysin Proteins blood
Immunosuppression Therapy
Linoleic Acid analysis
Male
Mice
Organ Size drug effects
Phagocytosis drug effects
Plant Extracts chemistry
Plant Extracts isolation & purification
Random Allocation
Spleen drug effects
Vitamin E analysis
Cornus chemistry
Immunity drug effects
Plant Extracts pharmacology
Plants, Medicinal chemistry
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1001-4454
- Volume :
- 33
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
- Publication Type :
- Academic Journal
- Accession number :
- 20575409