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Prevalence and genetic diversity of adeno-associated viruses in bats from China.
- Source :
-
The Journal of general virology [J Gen Virol] 2010 Oct; Vol. 91 (Pt 10), pp. 2601-9. Date of Electronic Publication: 2010 Jun 23. - Publication Year :
- 2010
-
Abstract
- Bats are increasingly being recognized as important natural reservoirs of different viruses. Adeno-associated viruses (AAVs) are widely distributed in primates and their distribution in bats is unknown. In this study, a total of 370 faecal swab samples from 19 bat species were collected from various provinces of China and examined for the presence of AAVs. The mean prevalence rate was 22.4% (83 positives out of 370 samples), ranging from 10 to 38.9% among different bat species. The genome sequence spanning the entire rep-cap ORFs was determined from one chosen AAV-positive sample (designated BtAAV-YNM). Phylogenetic analysis of the entire rep-cap ORF coding sequences suggested that BtAAV-YNM is relatively distant to known primate AAVs, but phylogenetically closer to porcine AAV strain Po3. Further analysis of the partial cap ORF sequences of bat AAV samples (n=49) revealed a remarkably large genetic diversity, with an average pairwise nucleotide identity of only 84.3%. Co-presence of multiple distinctive genotypes of bat AAV within an individual sample was also observed. These results demonstrated that diverse AAVs might be widely distributed in bat populations.
- Subjects :
- Animals
China epidemiology
Cluster Analysis
DNA, Viral chemistry
DNA, Viral genetics
Dependovirus genetics
Feces virology
Genotype
Molecular Sequence Data
Parvoviridae Infections epidemiology
Parvoviridae Infections virology
Phylogeny
Prevalence
Sequence Analysis, DNA
Sequence Homology
Viral Proteins genetics
Chiroptera virology
Dependovirus classification
Dependovirus isolation & purification
Genetic Variation
Parvoviridae Infections veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 1465-2099
- Volume :
- 91
- Issue :
- Pt 10
- Database :
- MEDLINE
- Journal :
- The Journal of general virology
- Publication Type :
- Academic Journal
- Accession number :
- 20573859
- Full Text :
- https://doi.org/10.1099/vir.0.020032-0