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Pro-inflammatory cytokine and chemokine mRNA blood level in multiple sclerosis is related to treatment response and interferon-beta dose.

Authors :
Cucci A
Barbero P
Clerico M
Ferrero B
Versino E
Contessa G
Demercanti S
Viglietta E
Di Liberto A
Vai AG
Durelli L
Source :
Journal of neuroimmunology [J Neuroimmunol] 2010 Sep 14; Vol. 226 (1-2), pp. 150-7. Date of Electronic Publication: 2010 Jun 23.
Publication Year :
2010

Abstract

Of 37 multiple sclerosis patients, 19 suboptimal responders were randomized to 375 (n=12) or 250µg (n=7) interferon (IFN)-β-1b. mRNA levels of 23 cytokines, chemokines, and chemokine receptors were quantified by TaqMan low-density array (TLDA) real-time polymerase chain reaction. Better treatment responses or increased IFN-β doses were associated with elevated IL-10 and TGF-β and decreased CXCL10, IL-18, IFN-γ, and TNF-α transcript levels. Adjusting for dose, poor treatment responses resulted in a 4-fold increase in CXCL10 and IFN-γ expression (Mantel-Haenszel RR=3.74, p<0.0001). CXCL10 and IFN-γ mRNA levels were reliable indicators of treatment response. TLDA can be used to tailor IFN-β-1b therapy.<br /> (Copyright © 2010 Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
1872-8421
Volume :
226
Issue :
1-2
Database :
MEDLINE
Journal :
Journal of neuroimmunology
Publication Type :
Academic Journal
Accession number :
20573405
Full Text :
https://doi.org/10.1016/j.jneuroim.2010.05.038