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Pro-inflammatory cytokine and chemokine mRNA blood level in multiple sclerosis is related to treatment response and interferon-beta dose.
- Source :
-
Journal of neuroimmunology [J Neuroimmunol] 2010 Sep 14; Vol. 226 (1-2), pp. 150-7. Date of Electronic Publication: 2010 Jun 23. - Publication Year :
- 2010
-
Abstract
- Of 37 multiple sclerosis patients, 19 suboptimal responders were randomized to 375 (n=12) or 250µg (n=7) interferon (IFN)-β-1b. mRNA levels of 23 cytokines, chemokines, and chemokine receptors were quantified by TaqMan low-density array (TLDA) real-time polymerase chain reaction. Better treatment responses or increased IFN-β doses were associated with elevated IL-10 and TGF-β and decreased CXCL10, IL-18, IFN-γ, and TNF-α transcript levels. Adjusting for dose, poor treatment responses resulted in a 4-fold increase in CXCL10 and IFN-γ expression (Mantel-Haenszel RR=3.74, p<0.0001). CXCL10 and IFN-γ mRNA levels were reliable indicators of treatment response. TLDA can be used to tailor IFN-β-1b therapy.<br /> (Copyright © 2010 Elsevier B.V. All rights reserved.)
- Subjects :
- Adult
Cytokines classification
Dose-Response Relationship, Drug
Female
Gene Expression Regulation drug effects
Humans
Interferon-beta pharmacology
Longitudinal Studies
Male
Young Adult
Cytokines blood
Cytokines genetics
Interferon-beta therapeutic use
Multiple Sclerosis drug therapy
Multiple Sclerosis immunology
RNA, Messenger blood
Subjects
Details
- Language :
- English
- ISSN :
- 1872-8421
- Volume :
- 226
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Journal of neuroimmunology
- Publication Type :
- Academic Journal
- Accession number :
- 20573405
- Full Text :
- https://doi.org/10.1016/j.jneuroim.2010.05.038