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IL-2 immunotherapy to recently HIV-1 infected adults maintains the numbers of IL-17 expressing CD4+ T (T(H)17) cells in the periphery.
- Source :
-
Journal of clinical immunology [J Clin Immunol] 2010 Sep; Vol. 30 (5), pp. 681-92. Date of Electronic Publication: 2010 Jun 23. - Publication Year :
- 2010
-
Abstract
- Little is known about the manipulation of IL-17 producing CD4+ T cells (T(H)17) on a per-cell basis in humans in vivo. Previous studies on the effects of IL-2 on IL-17 secretion in non-HIV models have shown divergent results. We hypothesized that IL-2 would mediate changes in IL-17 levels among recently HIV-1-infected adults receiving anti-retroviral therapy. We measured cytokine T cell responses to CD3/CD28, HIV-1 Gag, and CMV pp65 stimulation, and changes in multiple CD4+ T cell subsets. Those who received IL-2 showed a robust expansion of naive and total CD4+ T cell counts and T-reg counts. However, after IL-2 treatment, the frequency of T(H)17 cells declined, while counts of T(H)17 cells did not change due to an expansion of the CD4+ naïve T cell population (CD27+CD45RA+). Counts of HIV-1 Gag-specific T cells declined modestly, but CMV pp65 and CD3/CD28 stimulated populations did not change. Hence, in contrast with recent studies, our results suggest IL-2 is not a potent in vivo regulator of T(H)17 cell populations in HIV-1 disease. However, IL-2-mediated T-reg expansions may selectively reduce responses to certain antigen-specific populations, such as HIV-1 Gag.
- Subjects :
- Adult
Anti-Retroviral Agents therapeutic use
Antibodies, Monoclonal immunology
Antibodies, Monoclonal metabolism
CD4-Positive T-Lymphocytes immunology
CD4-Positive T-Lymphocytes virology
Cell Count
Cell Proliferation drug effects
Drug Therapy, Combination
HIV Infections drug therapy
HIV-1
Humans
Immunomodulation
Interleukin-17 biosynthesis
Interleukin-17 genetics
Interleukin-2 therapeutic use
Phosphoproteins immunology
T-Cell Antigen Receptor Specificity
Th17 Cells immunology
Th17 Cells pathology
Th17 Cells virology
Viral Matrix Proteins immunology
gag Gene Products, Human Immunodeficiency Virus immunology
CD4-Positive T-Lymphocytes drug effects
HIV Infections immunology
Immunotherapy
Interleukin-2 administration & dosage
Th17 Cells drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1573-2592
- Volume :
- 30
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of clinical immunology
- Publication Type :
- Academic Journal
- Accession number :
- 20571894
- Full Text :
- https://doi.org/10.1007/s10875-010-9432-3