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ACE inhibitors can induce circulating antibodies directed to antigens of the superficial epidermal cells.
- Source :
-
Archives of dermatological research [Arch Dermatol Res] 2011 Jul; Vol. 303 (5), pp. 327-32. Date of Electronic Publication: 2010 Jun 20. - Publication Year :
- 2011
-
Abstract
- Drug-induced pemphigus has been reported in patients receiving angiotensin-converting enzyme inhibitors. The aim of this work was to study a group of hypertensive patients without skin diseases treated with angiotensin-converting enzyme (ACE) Inhibitors (I), to verify the presence of serum circulating anti-antibodies. The indirect immunofluorescence showed that 33 sera (52.38%) presented autoantibodies directed to an antigen of the cytoplasm of the superficial epidermal keratinocytes. Two of the 33 positive sera had antibodies to Dsg1 and/or 3 in ELISA. Immunoblot analyses were negative. All the 48 control sera were found to have no circulating antibodies using the three assays. Our results would confirm that ACEI drugs may trigger the production of circulating autoantibodies also in patients without clinical manifestations of pemphigus.
- Subjects :
- Angiotensin-Converting Enzyme Inhibitors therapeutic use
Antibodies, Anti-Idiotypic blood
Antibody Formation
Autoantibodies immunology
Desmoglein 1 immunology
Desmoglein 3 immunology
Enzyme-Linked Immunosorbent Assay
Epidermis immunology
Female
Fluorescent Antibody Technique, Indirect
Humans
Hypertension drug therapy
Immunoblotting
Male
Pemphigus immunology
Angiotensin-Converting Enzyme Inhibitors adverse effects
Antigens immunology
Autoantibodies blood
Keratinocytes immunology
Skin Diseases chemically induced
Subjects
Details
- Language :
- English
- ISSN :
- 1432-069X
- Volume :
- 303
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Archives of dermatological research
- Publication Type :
- Academic Journal
- Accession number :
- 20563876
- Full Text :
- https://doi.org/10.1007/s00403-010-1060-5