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ACE inhibitors can induce circulating antibodies directed to antigens of the superficial epidermal cells.

Authors :
Cozzani E
Rosa GM
Drosera M
Intra C
Barsotti A
Parodi A
Source :
Archives of dermatological research [Arch Dermatol Res] 2011 Jul; Vol. 303 (5), pp. 327-32. Date of Electronic Publication: 2010 Jun 20.
Publication Year :
2011

Abstract

Drug-induced pemphigus has been reported in patients receiving angiotensin-converting enzyme inhibitors. The aim of this work was to study a group of hypertensive patients without skin diseases treated with angiotensin-converting enzyme (ACE) Inhibitors (I), to verify the presence of serum circulating anti-antibodies. The indirect immunofluorescence showed that 33 sera (52.38%) presented autoantibodies directed to an antigen of the cytoplasm of the superficial epidermal keratinocytes. Two of the 33 positive sera had antibodies to Dsg1 and/or 3 in ELISA. Immunoblot analyses were negative. All the 48 control sera were found to have no circulating antibodies using the three assays. Our results would confirm that ACEI drugs may trigger the production of circulating autoantibodies also in patients without clinical manifestations of pemphigus.

Details

Language :
English
ISSN :
1432-069X
Volume :
303
Issue :
5
Database :
MEDLINE
Journal :
Archives of dermatological research
Publication Type :
Academic Journal
Accession number :
20563876
Full Text :
https://doi.org/10.1007/s00403-010-1060-5