Back to Search
Start Over
Antiplasmodial activity of atisinium chloride from the Bhutanese medicinal plant, Aconitum orochryseum.
- Source :
-
Journal of ethnopharmacology [J Ethnopharmacol] 2010 Aug 09; Vol. 130 (3), pp. 559-62. Date of Electronic Publication: 2010 Jun 02. - Publication Year :
- 2010
-
Abstract
- Ethnopharmacological Relevance: The plant Aconitum orochryseum Stapf. (Ranunculaceae) is employed together with other plants in Bhutanese traditional medicine and is indicated for malaria-associated fever.<br />Aim of the Study: To study the in vitro antiplasmodial activity of atisinium chloride, the major alkaloid from Aconitum orochryseum.<br />Materials and Methods: Atisinium chloride was extracted and purified from aerial parts of Aconitum orochryseum and its structure and absolute configuration confirmed by single crystal X-ray crystallography. The crude methanol extract, crude alkaloid fraction, and atisinium chloride were tested for in vitro antiplasmodial activity against the malarial Plasmodium falciparum strains TM4/8.2 (TM4; wild type) and K1CB1 (K1; chloroquine and antifolate resistant).<br />Results: The diterpenoid alkaloid atisinium chloride was shown to have moderate antiplasmodial activities with IC(50) values of 4 microM and 3.6 microM, respectively against the TM4 strain and the K1 strain of Plasmodium falciparum.<br />Conclusions: Our studies provide the first evidence in support of one of the indicated treatments with Aconitum orochryseum in Bhutanese traditional medicine. This alkaloid also represents a potential new antimalarial structural lead.<br /> (Copyright 2010 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Alkaloids isolation & purification
Alkaloids pharmacology
Antimalarials administration & dosage
Antimalarials isolation & purification
Bhutan
Crystallography, X-Ray
Diterpenes administration & dosage
Diterpenes isolation & purification
Inhibitory Concentration 50
Medicine, Traditional
Plant Components, Aerial
Plant Extracts pharmacology
Aconitum chemistry
Antimalarials pharmacology
Diterpenes pharmacology
Plasmodium falciparum drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7573
- Volume :
- 130
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of ethnopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 20561926
- Full Text :
- https://doi.org/10.1016/j.jep.2010.05.057