Back to Search
Start Over
Clinical and laboratory features of invasive community-onset methicillin-resistant Staphylococcus aureus infection: a prospective case-control study.
- Source :
-
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology [Eur J Clin Microbiol Infect Dis] 2010 Aug; Vol. 29 (8), pp. 1025-33. Date of Electronic Publication: 2010 Jun 12. - Publication Year :
- 2010
-
Abstract
- Differences between the features of invasive community-onset methicillin-resistant Staphylococcus aureus (cMRSA) and methicillin-susceptible S. aureus (cMSSA) infections are incompletely understood. Fifty-seven patients with invasive cMRSA infection were prospectively identified at two teaching hospitals; for each cMRSA case, two cases of invasive cMSSA infection acted as controls. The primary outcome was 30-day all-cause mortality. Patients with invasive cMRSA infection were more likely to be Aboriginal (25% vs. 14%, age-adjusted odds ratio [OR] 2.5, p = 0.037), reside in a long-term care facility and/or have been hospitalised in the previous year (51% vs. 34%, p = 0.04) and less likely to have endocarditis (2% vs. 12%, p = 0.02) or require admission to an intensive care unit or high-dependency area (7% vs. 21%, p = 0.02). All-cause mortality at 30 days was similar in the cMRSA and cMSSA groups (9% vs. 7%, p = 0.68). Panton-Valentine leukocidin (PVL) genes were detected in a similar proportion of cMRSA and cMSSA isolates (32% vs. 27%, p = 0.49) and the presence of PVL genes was associated with younger age (35 years vs. 55 years, p < 0.001), Aboriginal ethnicity (38% vs. 10%, p < 0.001), skin and soft-tissue infection (54% vs. 19%, p < 0.001), lower illness severity at presentation (SAPS II score 9 vs. 21, p = 0.001) and shorter hospitalisation (9 days vs. 24 days, p < 0.001). Patients with "PVL-positive" and "PVL-negative" S. aureus infection had similar 30-day all-cause mortality (4% vs. 9%, p = 0.28). Few clinical features differentiated patients with invasive cMRSA infection from those with infection caused by cMSSA. Invasive "PVL-positive" S. aureus infection was associated with less morbidity but similar mortality to "PVL-negative" infection.
- Subjects :
- Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Bacterial Toxins genetics
Case-Control Studies
Child
Child, Preschool
Community-Acquired Infections mortality
Ethnicity
Exotoxins genetics
Female
Hospitalization statistics & numerical data
Hospitals, Teaching
Humans
Leukocidins genetics
Male
Methicillin-Resistant Staphylococcus aureus classification
Methicillin-Resistant Staphylococcus aureus genetics
Middle Aged
Prospective Studies
Risk Factors
Staphylococcal Infections mortality
Virulence Factors genetics
Young Adult
Community-Acquired Infections microbiology
Community-Acquired Infections pathology
Methicillin-Resistant Staphylococcus aureus isolation & purification
Staphylococcal Infections microbiology
Staphylococcal Infections pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1435-4373
- Volume :
- 29
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 20549534
- Full Text :
- https://doi.org/10.1007/s10096-010-0973-4