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Incidence of side effects using carbon dioxide-oxygen foam for chemical ablation of superficial veins of the lower extremity.
- Source :
-
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery [Eur J Vasc Endovasc Surg] 2010 Sep; Vol. 40 (3), pp. 407-13. Date of Electronic Publication: 2010 May 23. - Publication Year :
- 2010
-
Abstract
- Objectives: To determine the incidence of side effects following treatment of varicose veins with carbon dioxide-oxygen (CO(2)/O(2)) foam sclerotherapy, and to compare results with historical controls using CO(2)- or air-based foams.<br />Design: Cohort study with prospective data collection, private clinic setting.<br />Patients: The patient population consisted of one hundred patients, 95% women, age 52 SD 13 years-old, CEAP class C(2)EpAsPr.<br />Methods: Patients underwent ultrasound-guided foam sclerotherapy following thermal ablation of saphenous trunks; 1-3% polidocanol and 70%CO(2)-30%O(2) gas were mixed in a 1:4 proportion. Volume injected averaged 22 SD 11 (range: 2-46) mL. Vital signs were monitored for 1 h; side effects were recorded up to 24 h post treatment. Incidence of side effects was compared to CO(2)- and air-based foam data.<br />Results: Heart rate decreased from 73 SD 11 at the start to 68 SD 9 bpm (p < 0.001, paired t-test) following the procedure. Systolic and diastolic pressures, 127/75 SD 18/14 mmHg, respiratory rate, 15 SD 4 rpm and pO(2), 98 SD 2%, did not change significantly. Itching (7) or leg pain (24) reporting was similar to that for air-based foam (p = NS). Lack of reported chest tightness and/or dry cough was superior to our previous data with CO(2) or air foam (p < 0.05). Reporting of dizziness (1) was less than that for air-based foam (p = 0.002). The incidence of visual disturbance (2%), was comparable with that for CO(2) (3%) or air (8%) foam, but too few cases were available for meaningful statistical analysis.<br />Conclusions: Foam sclerotherapy using CO(2)/O(2) foam was well tolerated by patients and resulted in fewer side effects than similar treatment using air foams.<br /> (Copyright 2010 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Adult
Aged
Carbon Dioxide adverse effects
Female
Humans
Male
Middle Aged
Oxygen adverse effects
Polidocanol
Prospective Studies
Sclerosing Solutions adverse effects
Sclerotherapy adverse effects
Time Factors
Treatment Outcome
Ultrasonography, Interventional
Varicose Veins diagnostic imaging
Carbon Dioxide therapeutic use
Lower Extremity blood supply
Oxygen therapeutic use
Polyethylene Glycols therapeutic use
Sclerosing Solutions therapeutic use
Sclerotherapy methods
Varicose Veins therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1532-2165
- Volume :
- 40
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery
- Publication Type :
- Academic Journal
- Accession number :
- 20547080
- Full Text :
- https://doi.org/10.1016/j.ejvs.2010.04.018