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Randomised comparison of titanium-nitride-oxide coated stents with bare metal stents: five year follow-up of the TiNOX trial.
- Source :
-
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology [EuroIntervention] 2010 May; Vol. 6 (1), pp. 63-8. - Publication Year :
- 2010
-
Abstract
- Aims: Revascularisation with Titanium-Nitride-Oxide (TiNOX) coated stents is safe and effective in patients with de novo native coronary artery lesions. In the TiNOX trial there was a reduction in restenosis and major adverse cardiac events as compared with stainless steel stents of otherwise identical design. The purpose of the present study was to evaluate the long-term outcome of these patients over five years.<br />Methods and Results: In 2003, 92 patients with de novo lesions were randomly assigned to treatment with TiNOX coated stents (n=45) or stainless steel stents (n=47; control). Baseline characteristics were similar in both groups. Follow-up at six months and five years was obtained in 87 patients. Five patients were lost to follow-up due to emigration or change in home address. At six months and five years, significantly less major adverse cardiac events (MACE) occurred in the TiNOX group (7% vs. 27%, [p=0.02] respectively and 16% vs. 39%, [p=0.03]), largely driven by a reduced need for target-lesion revascularisation. No stent thrombosis occurred in the TiNOX group vs. one in the control group. Patients in the TiNOX-group had lower all-cause mortality and less myocardial infarction, but the difference was not statistically significant.<br />Conclusions: Five-year follow-up after implantation of titanium-nitride-oxide coated stents is favourable with a low rate of MACE and no stent thrombosis compared to bare metal stents of identical design. The need for revascularisation at five years was 9% in the TiNOX and 25% in the control group with little progression of native coronary disease.
- Subjects :
- Aged
Angioplasty, Balloon, Coronary adverse effects
Angioplasty, Balloon, Coronary mortality
Coronary Angiography
Coronary Artery Disease diagnostic imaging
Coronary Artery Disease mortality
Female
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Myocardial Infarction etiology
Myocardial Infarction prevention & control
Prosthesis Design
Thrombosis etiology
Thrombosis prevention & control
Time Factors
Treatment Outcome
Angioplasty, Balloon, Coronary instrumentation
Coated Materials, Biocompatible
Coronary Artery Disease therapy
Stainless Steel
Stents
Titanium
Subjects
Details
- Language :
- English
- ISSN :
- 1969-6213
- Volume :
- 6
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 20542799