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Dietary restriction modifies certain aspects of the postoperative acute phase response.
- Source :
-
The Journal of surgical research [J Surg Res] 2011 Dec; Vol. 171 (2), pp. 582-9. Date of Electronic Publication: 2010 Apr 13. - Publication Year :
- 2011
-
Abstract
- Background: Lifespan extension is achieved through long-term application of dietary restriction (DR), and benefits of short-term dietary restriction on acute stress and inflammation have been observed. So far, the effects of short-term DR in humans are relatively unknown. We hypothesized that short-term DR in humans reduces the acute phase response following a well defined surgical trauma.<br />Methods: Thirty live kidney donors were randomized between 30% preoperative dietary restriction followed by 1 d of fasting (n=17) or a 4 d ad libitum regimen (n=13) prior to surgery. Leukocyte subsets and numbers and serum cytokine levels were determined. Whole blood was stimulated with lipopolysaccharide (LPS) and cytokine production was determined.<br />Results: A clear trend towards lower numbers of postoperative circulating leukocytes was observed in the DR group. IL-8 serum levels were significantly higher in the DR group over the first 6 postoperative d (P=0.018). After LPS stimulation, significantly less TNF-α (P=0.001) was produced by blood obtained postoperatively compared with preoperative blood from the DR group. This was not observed in the control group.<br />Conclusions: A relatively short preoperative dietary restriction regimen was able to modify certain aspects of the postoperative acute phase response. These data warrant further studies into the dietary conditions that improve stress resistance in humans. (Dutch Trial Registry number: NTR1875).<br /> (Copyright © 2011 Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Aged
C-Reactive Protein metabolism
Cytokines metabolism
Fasting physiology
Female
Humans
Leukocyte Count
Leukocytes drug effects
Leukocytes immunology
Lipopolysaccharides pharmacology
Male
Middle Aged
Acute-Phase Reaction immunology
Caloric Restriction methods
Nephrectomy
Stress, Physiological immunology
Tissue Donors
Subjects
Details
- Language :
- English
- ISSN :
- 1095-8673
- Volume :
- 171
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The Journal of surgical research
- Publication Type :
- Academic Journal
- Accession number :
- 20538300
- Full Text :
- https://doi.org/10.1016/j.jss.2010.03.038