Recurrent acute obstructive hydrocephalus as clinical onset of cerebral Whipple's disease.

Authors :: Seneca V
Imperato A
Colella G
Cioffi V
Mariniello G
Gangemi M
Source :: Clinical neurology and neurosurgery [Clin Neurol Neurosurg] 2010 Oct; Vol. 112 (8), pp. 717-21.
Publication Year :: 2010
Abstract: Whipple's disease is a rare multisystemic infection caused by the intracellular bacteria Thropheryma whippelii. Central nervous system (CNS) involvement is not rare. The most frequent CNS manifestations are cognitive and behavioural changes, sopranuclear ophtalmoplegia, myoclonus, epilepsy, ataxia, meningitis and focal cerebral palsy. We report one case of cerebral localization of Whipple's disease with a clinical presentation of recurrent endocranic hypertension and hydrocephalus, and uncommon neurological symptoms, successfully treated by endoscopic third ventriculostomy and antibiotic therapy with ceftriaxone and Trimethoprim-Sulfamethoxazole.<br /> ((c) 2010 Elsevier B.V. All rights reserved.)

Subjects :: Acute Disease
Adult
Anti-Infective Agents therapeutic use
Cerebral Ventriculitis drug therapy
Cerebral Ventriculitis microbiology
Drug Therapy, Combination
Humans
Hydrocephalus microbiology
Intracranial Hypertension microbiology
Male
Recurrence
Treatment Outcome
Ventriculostomy
Whipple Disease drug therapy
Cerebral Ventriculitis complications
Hydrocephalus etiology
Intracranial Hypertension etiology
Whipple Disease complications

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