Back to Search
Start Over
Impact of genomic polymorphism on arterial hypertension after aortic coarctation repair.
- Source :
-
International journal of cardiology [Int J Cardiol] 2011 Aug 18; Vol. 151 (1), pp. 63-8. Date of Electronic Publication: 2010 Jun 07. - Publication Year :
- 2011
-
Abstract
- Objective: Even after repair of aortic coarctation without restenosis there is a high incidence of arterial hypertension. This study was performed to assess the contribution of several inherited gene polymorphisms, which are known to be related to essential hypertension.<br />Patients and Methods: 122 patients aged 17-72 years, 46 women, and 2-27 years after repair of isolated aortic coarctation without restenosis were investigated. Genomic polymorphism of angiotensin converting enzyme (ACE I/D), angiotensinogen (AGT, c.704C>T), angiotensin II receptor type 1 (AGTR1, c.1166A>C), aldosterone synthase (CYP11B2, c.-344C>T), endothelin 1 (EDN1, EDN1/ex5-c.5665G>T), G protein (GNB3, c.825C>T), G protein-coupled receptor kinase 4 (GRK4, c.679C>T), fibrillin 1 (FBN1, VNTR(TAAA)) and two polymorphisms each of the ß1 adrenoreceptor (ADRB1, c.145G>A and c.1165C>G), ß2 adrenoreceptor (ADRB2, c.46A>G and c.79C>G), and endothelial NO synthase (NOS3, intron 4 I/D and NOS3, c.894G>T) were determined by PCR amplification and fragment length analysis. Patients were classified "normotensive", if they were not on antihypertensive drugs and showed normal blood pressure both on ambulatory measurement and exercise test.<br />Results: None of the investigated genomic polymorphism could be related to hypertension. Only patients with the ACE I/I genotype had a less pronounced nocturnal dipping and patients with a ADRB1 c.1165 C/C genotype had a higher systolic and mean blood pressure at night.<br />Conclusions: Development of late hypertension after aortic coarctation repair could not be related to the investigated genomic polymorphism. The correlation of the ACE I/D and the ADRB1 c.1165C>G polymorphism to nocturnal dipping and blood pressure at nighttime needs further confirmation.<br /> (Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Adolescent
Adult
Aged
Blood Pressure
Cardiac Surgical Procedures
Circadian Rhythm
Female
Follow-Up Studies
Genotype
Humans
Male
Middle Aged
Phenotype
Postoperative Complications genetics
Young Adult
Aortic Coarctation genetics
Aortic Coarctation surgery
Hypertension genetics
Peptidyl-Dipeptidase A genetics
Polymorphism, Genetic
Receptors, Adrenergic, beta-1 genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1874-1754
- Volume :
- 151
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- International journal of cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 20537417
- Full Text :
- https://doi.org/10.1016/j.ijcard.2010.04.090