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Antiphospholipid antibodies and antiphospholipid syndrome: role in portal vein thrombosis in patients with and without liver cirrhosis.
- Source :
-
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis [Clin Appl Thromb Hemost] 2011 Aug; Vol. 17 (4), pp. 367-70. Date of Electronic Publication: 2010 Jun 07. - Publication Year :
- 2011
-
Abstract
- Unlabelled: The antiphospholipid syndrome (APS) has been associated with portal vein thrombosis (PVT). This study explored the contribution of antiphospholipid antibodies (aPL) to PVT in cirrhotic and noncirrhotic patients.<br />Patients and Methods: A total of 50 patients with liver cirrhosis and PVT, 50 patients with liver cirrhosis without PVT, 50 consecutive PVT without liver cirrhosis, and 50 controls. aPL tests: lupus anticoagulants (LAs), immunoglobulin G (IgG) anti-cardiolipin antibodies (aCL), IgG anti-beta-2-glycoprotein-I (β(2)GPI), and IgG β( 2)GPI-complexed with oxidized low-density lipoprotein antibodies (ox-LDL).<br />Results: Lupus anticoagulants were negative in all patients. A titre of IgG aCL >40 IgG phospholipid units (GPL) was present in 2% of patients with liver cirrhosis and in none of the other groups. In all, 4% of patients with PVT without cirrhosis were positive for IgG β(2)GPI in the absence of any other positive aPL and labelled as primary APS.<br />Conclusions: aPL play no role in PVT associated with liver cirrhosis but can be tested in idiopathic PVT.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Antiphospholipid Syndrome complications
Female
Humans
Liver Cirrhosis complications
Male
Middle Aged
Thrombosis complications
Young Adult
Antibodies, Antiphospholipid immunology
Antiphospholipid Syndrome immunology
Liver Cirrhosis immunology
Portal Vein
Thrombosis immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1938-2723
- Volume :
- 17
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
- Publication Type :
- Academic Journal
- Accession number :
- 20530055
- Full Text :
- https://doi.org/10.1177/1076029610369797