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Vitreoretinal interface abnormalities in healed cytomegalovirus retinitis.
- Source :
-
Retina (Philadelphia, Pa.) [Retina] 2010 Sep; Vol. 30 (8), pp. 1262-6. - Publication Year :
- 2010
-
Abstract
- Purpose: The purpose of this study was to use spectral domain-optical coherence tomography in imaging retina and vitreoretinal relationship in healed cytomegalovirus (CMV) retinitis.<br />Methods: Patients with a history of confirmed CMV retinitis and a healed CMV scar on clinical examination underwent spectral domain-optical coherence tomography examinations using a Spectralis Heidelberg retinal angiograph/optical coherence tomography instrument (Heidelberg Engineering, Heidelberg, Germany). Horizontal and vertical cross-sectional B-scans 6 mm x 6 mm passing through the center and margins of healed CMV scars and adjacent retina were obtained. We analyzed the integrity of retinal layers in the area of the CMV scar, integrity of retinal layers at the margins of the CMV scar, margins of the scar and adjacent nonaffected retina, and any structural alterations in the retina or vitreous.<br />Results: Eleven eyes (50%) had vitreous detached, and 11 eyes attached over the area of healed retinitis. Nineteen eyes (86%) had an epiretinal membrane, and 12 eyes (54%) had vitreoretinal gliosis present over the healed retinitis or in its vicinity. The epiretinal membrane and vitreoretinal gliosis occurred concomitantly in 10 eyes and could be well differentiated on scans. None of these were found in control eyes.<br />Conclusion: This first in vivo study of vitreoretinal interface in inactive CMV retinitis shows that the vitreoretinal interface in healed CMV is pathologically changed. The presence of epiretinal membranes, vitreoretinal gliosis, and traction may help explain the higher incidence of retinal elevation, retinal breaks, and retinal detachment in these eyes.
- Subjects :
- AIDS-Related Opportunistic Infections diagnosis
AIDS-Related Opportunistic Infections drug therapy
Antiviral Agents therapeutic use
Cytomegalovirus Retinitis drug therapy
Female
Humans
Male
Middle Aged
Retrospective Studies
Tomography, Optical Coherence
Cytomegalovirus Retinitis diagnosis
Epiretinal Membrane diagnosis
Gliosis diagnosis
Retina pathology
Vitreous Body pathology
Vitreous Detachment diagnosis
Wound Healing
Subjects
Details
- Language :
- English
- ISSN :
- 1539-2864
- Volume :
- 30
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Retina (Philadelphia, Pa.)
- Publication Type :
- Academic Journal
- Accession number :
- 20517176
- Full Text :
- https://doi.org/10.1097/IAE.0b013e3181cea6c1