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Comparison of survival after surgical or medical treatment in dogs with a congenital portosystemic shunt.
- Source :
-
Journal of the American Veterinary Medical Association [J Am Vet Med Assoc] 2010 Jun 01; Vol. 236 (11), pp. 1215-20. - Publication Year :
- 2010
-
Abstract
- Objective: To compare survival of dogs with a congenital portosystemic shunt (CPSS) that received medical or surgical treatment.<br />Design: Prospective cohort study.<br />Animals: 126 client-owned dogs with a single CPSS.<br />Procedures: Dogs were examined at 1 of 3 referral clinics, and a single CPSS was diagnosed in each. Dogs received medical or surgical treatment without regard to signalment, clinical signs, or results of hematologic or biochemical analysis. Survival data were analyzed via a Cox regression model.<br />Results: During a median follow-up period of 579 days, 18 of 126 dogs died as a result of CPSS. Dogs treated via surgical intervention survived significantly longer than did those treated medically. Hazard ratio for medical versus surgical treatment of CPSS (for the treatment-only model) was 2.9 (95% confidence interval, 1.1 to 7.2). Age at CPSS diagnosis did not affect survival.<br />Conclusions and Clinical Relevance: Both medical and surgical treatment can be used to achieve long-term survival of dogs with CPSS, although results of statistical analysis supported the widely held belief that surgery is preferable to medical treatment. However, the study population consisted of dogs at referral clinics, which suggested that efficacy of medical treatment may have been underestimated. Although surgical intervention was associated with a better chance of long-term survival, medical management provided an acceptable first-line option. Age at examination did not affect survival, which implied that early surgical intervention was not essential. Dogs with CPSS that do not achieve acceptable resolution with medical treatment can subsequently be treated surgically.
- Subjects :
- Animals
Diet veterinary
Dog Diseases congenital
Dog Diseases mortality
Dogs
Female
Liver Diseases congenital
Liver Diseases mortality
Liver Diseases therapy
Male
Portal System surgery
Anti-Bacterial Agents therapeutic use
Disaccharides therapeutic use
Dog Diseases therapy
Liver Diseases veterinary
Portal System abnormalities
Subjects
Details
- Language :
- English
- ISSN :
- 0003-1488
- Volume :
- 236
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Journal of the American Veterinary Medical Association
- Publication Type :
- Academic Journal
- Accession number :
- 20513200
- Full Text :
- https://doi.org/10.2460/javma.236.11.1215