Back to Search
Start Over
A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.
- Source :
-
Nature genetics [Nat Genet] 2010 Jul; Vol. 42 (7), pp. 599-603. Date of Electronic Publication: 2010 May 30. - Publication Year :
- 2010
-
Abstract
- To identify genetic susceptibility loci for nasopharyngeal carcinoma (NPC), a genome-wide association study was performed using 464,328 autosomal SNPs in 1,583 NPC affected individuals (cases) and 1,894 controls of southern Chinese descent. The top 49 SNPs from the genome-wide association study were genotyped in 3,507 cases and 3,063 controls of southern Chinese descent from Guangdong and Guangxi. The seven supportive SNPs were further confirmed by transmission disequilibrium test analysis in 279 trios from Guangdong. We identified three new susceptibility loci, TNFRSF19 on 13q12 (rs9510787, Pcombined=1.53x10(-9), odds ratio (OR)=1.20), MDS1-EVI1 on 3q26 (rs6774494, Pcombined=1.34x10(-8), OR=0.84) and the CDKN2A-CDKN2B gene cluster on 9p21 (rs1412829, Pcombined=4.84x10(-7), OR=0.78). Furthermore, we confirmed the role of HLA by revealing independent associations at rs2860580 (Pcombined=4.88x10(-67), OR=0.58), rs2894207 (Pcombined=3.42x10(-33), OR=0.61) and rs28421666 (Pcombined=2.49x10(-18), OR=0.67). Our findings provide new insights into the pathogenesis of NPC by highlighting the involvement of pathways related to TNFRSF19 and MDS1-EVI1 in addition to HLA molecules.
- Subjects :
- Asian People genetics
China
DNA-Binding Proteins genetics
Gene Frequency
Genetic Predisposition to Disease ethnology
Genotype
Humans
MDS1 and EVI1 Complex Locus Protein
Nasopharyngeal Neoplasms ethnology
Neoplasm Proteins genetics
Odds Ratio
Proto-Oncogenes genetics
Receptors, Tumor Necrosis Factor genetics
Risk Factors
Transcription Factors genetics
Genetic Predisposition to Disease genetics
Genome-Wide Association Study methods
Nasopharyngeal Neoplasms genetics
Polymorphism, Single Nucleotide
Subjects
Details
- Language :
- English
- ISSN :
- 1546-1718
- Volume :
- 42
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Nature genetics
- Publication Type :
- Academic Journal
- Accession number :
- 20512145
- Full Text :
- https://doi.org/10.1038/ng.601