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Allogeneic haematopoietic cell transplantation after nonmyeloablative conditioning in patients with T-cell and natural killer-cell lymphomas.
- Source :
-
British journal of haematology [Br J Haematol] 2010 Jul; Vol. 150 (2), pp. 170-8. Date of Electronic Publication: 2010 May 09. - Publication Year :
- 2010
-
Abstract
- Patients with T-cell and natural killer-cell lymphomas have poor outcomes. This study examined the role of allogeneic haematopoietic cell transplantation (allo-HCT) after nonmyeloablative conditioning in this setting. Seventeen patients with T-cell lymphoma or NK-cell lymphoma, including three patients in first complete remission, received allo-HCT after 2 Gy total-body irradiation and fludarabine. The median age was 57 (range, 18-73) years. The median number of prior therapies was 3 (range, 1-7), six patients (35%) had failed prior autologous HCT, and five patients (29%) had refractory disease at the time of allograft. Postgrafting immunosuppression was provided with mycophenolate mofetil with ciclosporin or tacrolimus. After a median follow-up of 3.3 (range, 0.3-8.0) years among surviving patients, the estimated probabilities of 3-year overall and progression-free survival were 59% and 53%, respectively, while the estimated probabilities of non-relapse mortality and relapse at 3 years were 19% and 26%, respectively. Sixty-five percent of patients developed grades 2-4 acute graft-versus-host disease and 53% of patients developed chronic graft-versus-host disease. Allo-HCT after nonmyeloablative conditioning is a promising salvage option for selected patients with T-cell and NK-cell lymphomas. These results suggest that graft-versus-T-cell lymphoma activity is responsible for long-term disease control.
- Subjects :
- Acute Disease
Adolescent
Adult
Aged
Chronic Disease
Disease Progression
Female
Graft Survival
Graft vs Host Disease etiology
Graft vs Tumor Effect
Hematopoietic Stem Cell Transplantation adverse effects
Histocompatibility Testing
Humans
Immunosuppression Therapy methods
Killer Cells, Natural pathology
Lymphoma, T-Cell immunology
Male
Middle Aged
Survival Analysis
Transplantation Conditioning adverse effects
Treatment Outcome
Young Adult
Hematopoietic Stem Cell Transplantation methods
Lymphoma, T-Cell therapy
Transplantation Conditioning methods
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2141
- Volume :
- 150
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- British journal of haematology
- Publication Type :
- Academic Journal
- Accession number :
- 20507311
- Full Text :
- https://doi.org/10.1111/j.1365-2141.2010.08210.x