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A new tool for photoaffinity labeling studies: a partially constrained, benzophenone based, alpha-amino acid.
- Source :
-
Organic & biomolecular chemistry [Org Biomol Chem] 2010 Jul 21; Vol. 8 (14), pp. 3281-6. Date of Electronic Publication: 2010 May 26. - Publication Year :
- 2010
-
Abstract
- The novel alpha-amino acid BpAib, a partially conformationally restricted analogue of the currently extensively used 3-(4-benzoylphenyl)alanine (Bpa) photoaffinity label, was synthesized, optically resolved, fully characterized, and appropriately derivatized. An intermolecular photocrosslinking experiment highlighted its regioselective reactivity towards the S-methyl side-chain group of a Met-based dipeptide, which is closely comparable to that of Bpa.
Details
- Language :
- English
- ISSN :
- 1477-0539
- Volume :
- 8
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- Organic & biomolecular chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 20505870
- Full Text :
- https://doi.org/10.1039/c003943h