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Bench-to-bedside review: vaccine protection strategies during pandemic flu outbreaks.
- Source :
-
Critical care (London, England) [Crit Care] 2010; Vol. 14 (2), pp. 218. Date of Electronic Publication: 2010 Apr 16. - Publication Year :
- 2010
-
Abstract
- Vaccination is the most effective means for the prevention of influenza, including pandemic strains. An ideal pandemic influenza vaccine should provide effective protection with the fewest number of doses in the shortest amount of time, and among the greatest proportion of the population. The current manufacturing processes required for embryonated chicken-egg-based influenza vaccines are limited in their ability to respond to pandemic situations - these limitations include problems with surge capacity, the need for egg-adapted strains, the possibility of contamination, and the presence of trace egg protein. Several vaccine strategies to circumvent the deficiencies intrinsic to an egg-based influenza vaccine are in various phases of development. These include the use of cell-culture-based growth systems, concomitant use of adjuvants, whole virus vaccines, recombinant protein vaccines, plasmid DNA vaccines, virus-like particle vaccines, and universal flu vaccines.
Details
- Language :
- English
- ISSN :
- 1466-609X
- Volume :
- 14
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Critical care (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 20497595
- Full Text :
- https://doi.org/10.1186/cc8891