Mutation analysis of the C1QTNF3 gene in patients with schizophrenia.

Authors :: Bespalova I
Angelo G
Ritter B
Rossy-Fullana E
Carrion-Baralt J
Durner M
Silverman J
Source :: Psychiatry research [Psychiatry Res] 2010 Sep 30; Vol. 179 (2), pp. 235-7. Date of Electronic Publication: 2010 May 18.
Publication Year :: 2010
Abstract: We previously identified a small region on chromosome 5p13 related to schizophrenia in a Puerto Rican pedigree. We screened one of the positional candidate genes, C1QTNF3, for mutations in affected family members. The direct sequencing identified 10 sequence variants, including five shared by all affected family members. Genotyping of the shared variants in a Puerto Rican sample of 118 cases and 136 controls did not reveal either allelic or genotype association with schizophrenia.<br /> (Copyright © 2009 Elsevier Ltd. All rights reserved.)