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Budesonide/formoterol pressurized metered-dose inhaler for patients with persistent asthma.
- Source :
-
Allergy and asthma proceedings [Allergy Asthma Proc] 2010 May-Jun; Vol. 31 (3), pp. 190-202. - Publication Year :
- 2010
-
Abstract
- The combination of budesonide and formoterol administered in one hydrofluoroalkane pressurized metered-dose inhaler (pMDI) is approved in the United States in two dosage strengths (budesonide/formoterol pMDI 80/4.5 microg x 2 inhalations [160/9 microg] or 160/4.5 microg x 2 inhalations [320/9 microg]) in a fixed-dose, twice-daily regimen for the treatment of patients > or =12 years old with persistent asthma not adequately controlled with an inhaled corticosteroid (ICS) alone. This article reviews the clinical profile of budesonide/formoterol pMDI in patients with persistent asthma, including information on pharmacogenetics, efficacy, and tolerability. Studies of budesonide/formoterol pMDI in patients with asthma were identified through PubMed and respiratory meeting abstract databases. Budesonide/formoterol pMDI 160/9 microg has shown a rapid onset (within 15 minutes) of clinically significant bronchodilation that is faster than fluticasone propionate/salmeterol dry powder inhaler (DPI) 250/50 microg (within 30 minutes). The efficacy and tolerability profile of budesonide/formoterol pMDI 320/9 microg was similar to fluticasone propionate/salmeterol DPI 250/50 microg and budesonide/formoterol DPI 320/9 microg in adults and adolescents with persistent asthma. Short-term (12-week) and long-term (6- to 12-month) studies have established greater efficacy and similar tolerability of budesonide/formoterol pMDI compared with its monocomponents and placebo in patients with mild/moderate or moderate/severe persistent asthma. Studies evaluating patient-reported outcomes, including health-related quality of life and patient satisfaction with treatment, further support the benefits of budesonide/formoterol pMDI in patients with persistent asthma. In summary, budesonide/formoterol pMDI is an effective, well-tolerated treatment option for patients with persistent asthma for whom ICS/long-acting beta2-adrenergic agonist combination therapy is appropriate.
- Subjects :
- Adolescent
Adrenergic beta-2 Receptor Agonists adverse effects
Adult
Bronchodilator Agents adverse effects
Budesonide adverse effects
Drug Combinations
Ethanolamines adverse effects
Formoterol Fumarate
Humans
Pharmacogenetics
Randomized Controlled Trials as Topic
Toxicity Tests
Adrenergic beta-2 Receptor Agonists administration & dosage
Asthma drug therapy
Bronchodilator Agents administration & dosage
Budesonide administration & dosage
Ethanolamines administration & dosage
Metered Dose Inhalers
Subjects
Details
- Language :
- English
- ISSN :
- 1539-6304
- Volume :
- 31
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Allergy and asthma proceedings
- Publication Type :
- Academic Journal
- Accession number :
- 20482961
- Full Text :
- https://doi.org/10.2500/aap.2010.31.3356