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The hand-foot-syndrome associated with medical tumor therapy - classification and management.
- Source :
-
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG [J Dtsch Dermatol Ges] 2010 Sep; Vol. 8 (9), pp. 652-61. Date of Electronic Publication: 2010 May 06. - Publication Year :
- 2010
-
Abstract
- The hand-foot-syndrome (HFS, palmoplantar erythrodysesthesia, chemotherapy-associated acral erythema) is characterized by painful predominantly palmo-plantar lesions. The association with different chemotherapeutic agents has been known for over 20 years. More recently, HFS has been reported in association with regimens using targeted agents, in particular the multikinase inhibitors (MKI) sorafenib and sunitinib. The HFS associated with MKI has a different distribution and clinical appearance than the traditional disorder. In this review, similarities and differences between chemotherapy- and MKI-associated HFS are discussed and current recommendations for their prophylaxis and management are summarized.
- Subjects :
- Antineoplastic Agents therapeutic use
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Antineoplastic Combined Chemotherapy Protocols toxicity
Benzenesulfonates therapeutic use
Benzenesulfonates toxicity
Dose-Response Relationship, Drug
Drug Administration Schedule
Drug Eruptions classification
Drug Eruptions diagnosis
Foot Dermatoses classification
Foot Dermatoses diagnosis
Hand Dermatoses classification
Hand Dermatoses diagnosis
Humans
Keratoderma, Palmoplantar chemically induced
Keratoderma, Palmoplantar classification
Keratoderma, Palmoplantar diagnosis
Keratoderma, Palmoplantar therapy
Niacinamide analogs & derivatives
Phenylurea Compounds
Protein Kinase Inhibitors therapeutic use
Protein Kinase Inhibitors toxicity
Pyridines therapeutic use
Pyridines toxicity
Sorafenib
Antineoplastic Agents toxicity
Dermatologic Agents therapeutic use
Drug Eruptions therapy
Foot Dermatoses chemically induced
Foot Dermatoses therapy
Hand Dermatoses chemically induced
Hand Dermatoses therapy
Neoplasms drug therapy
Subjects
Details
- Language :
- English; German
- ISSN :
- 1610-0387
- Volume :
- 8
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
- Publication Type :
- Academic Journal
- Accession number :
- 20482685
- Full Text :
- https://doi.org/10.1111/j.1610-0387.2010.07449.x