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Psychiatric features in children with genetic syndromes: toward functional phenotypes.
- Source :
-
Child and adolescent psychiatric clinics of North America [Child Adolesc Psychiatr Clin N Am] 2010 Apr; Vol. 19 (2), pp. 229-61, viii. - Publication Year :
- 2010
-
Abstract
- Neurodevelopmental disorders with identified genetic etiologies present a unique opportunity to study gene-brain-behavior connections in child psychiatry. Parsing complex human behavior into dissociable components is facilitated by examining a relatively homogenous genetic population. As children with developmental delay carry a greater burden of mental illness than the general population, familiarity with the most common genetic disorders will serve practitioners seeing a general child population. In this article basic genetic testing and 11 of the most common genetic disorders are reviewed, including the evidence base for treatment. Based on their training in child development, family systems, and multimodal treatment, child psychiatrists are well positioned to integrate cognitive, behavioral, social, psychiatric, and physical phenotypes, with a focus on functional impairment.<br /> (Copyright 2010 Elsevier Inc. All rights reserved.)
- Subjects :
- Angelman Syndrome epidemiology
Angelman Syndrome genetics
Attention Deficit Disorder with Hyperactivity epidemiology
Child
Cognition Disorders epidemiology
Fragile X Mental Retardation Protein genetics
Fragile X Syndrome epidemiology
Fragile X Syndrome genetics
Health Status
Humans
Mental Disorders epidemiology
Methyl-CpG-Binding Protein 2 genetics
Point Mutation genetics
Polymerase Chain Reaction
Prader-Willi Syndrome epidemiology
Prader-Willi Syndrome genetics
Rett Syndrome epidemiology
Williams Syndrome epidemiology
Williams Syndrome genetics
Down Syndrome genetics
Mental Disorders genetics
Phenotype
Rett Syndrome genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1558-0490
- Volume :
- 19
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Child and adolescent psychiatric clinics of North America
- Publication Type :
- Academic Journal
- Accession number :
- 20478498
- Full Text :
- https://doi.org/10.1016/j.chc.2010.02.001