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Looking for a 5-HT7 radiotracer for positron emission tomography.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Jun 15; Vol. 20 (12), pp. 3730-3. Date of Electronic Publication: 2010 Apr 24. - Publication Year :
- 2010
-
Abstract
- In search of a serotonin 5-HT(7) radiotracer for positron emission tomography, we developed 1-[2-[(2S)-1-(phenylsulfonyl)pyrrolidin-2-yl]ethyl]piperidin-4-yl 4-fluorobenzoate. After labeling in good yield with fluorine-18 via nitro for fluorine exchange, preliminary biological experiments with autoradiographies failed to evidence any specific 5-HT(7) receptor delineation.<br /> (Copyright 2010 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Autoradiography
Benzoates chemistry
Brain metabolism
Hydrophobic and Hydrophilic Interactions
Isotope Labeling
Radiopharmaceuticals chemistry
Radiopharmaceuticals pharmacokinetics
Rats
Benzoates pharmacokinetics
Fluorine Radioisotopes
Positron-Emission Tomography methods
Receptors, Serotonin analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 20
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 20471259
- Full Text :
- https://doi.org/10.1016/j.bmcl.2010.04.076