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Effects of a 1-year dietary intervention with n-3 polyunsaturated fatty acid-enriched olive oil on non-alcoholic fatty liver disease patients: a preliminary study.
- Source :
-
International journal of food sciences and nutrition [Int J Food Sci Nutr] 2010 Dec; Vol. 61 (8), pp. 792-802. Date of Electronic Publication: 2010 May 13. - Publication Year :
- 2010
-
Abstract
- Background and Aims: Non-alcoholic fatty liver disease (NAFLD) is a worldwide diffuse condition due to alimentary, environment and genetic factors. The aim of our preliminary study was to evaluate the effectiveness of long-term consumption of food enriched with n-3 polyunsaturated fatty acids (PUFA) in patients with NAFLD.<br />Methods: Eleven patients were enrolled; six (four males, two females) were planned for oral administration of 6.5 ml olive oil enriched with n-3 PUFA for 12 months, while five (four males, one female) were used as controls.<br />Results: Consumption of olive oil enriched with n-3 PUFA demonstrated a significant improvement of liver echo-texture and of the Doppler Perfusion Index after 12 months (after: 0.19 ± 0.02 vs. pre: 0.15 ± 0.03; P < 0.05), whereas no significant changes were seen at the end of follow-up in controls. Moreover, patients who consumed the olive oil enriched with n-3 PUFA showed a significant amelioration of liver enzymes, and of triglycerides (post: 132.8 ± 63.7 vs. pre: 164.5 ± 85.5 mg/dl; P = 0.04) in a general linear model adjusted for age and gender. Interestingly, patients reported to have a significant increase of adiponectin levels (post: 1,487.9 ± 96.7 vs. pre: 1,143 ± 24.8 μg/ml; P = 0.04).<br />Conclusion: The results of this preliminary study showed that long-term consumption of olive oil enriched with n-3 PUFA in patients with NAFLD is able to decrease circulating liver enzymes and triglycerides, with a significant improvement of adiponectin levels.
- Subjects :
- Adiponectin blood
Adult
Aged
Enzymes blood
Fatty Acids, Omega-3 pharmacology
Fatty Liver blood
Fatty Liver enzymology
Female
Humans
Liver enzymology
Male
Middle Aged
Olive Oil
Pilot Projects
Dietary Fats administration & dosage
Fatty Acids, Omega-3 therapeutic use
Fatty Liver drug therapy
Food, Fortified
Liver drug effects
Plant Oils
Triglycerides blood
Subjects
Details
- Language :
- English
- ISSN :
- 1465-3478
- Volume :
- 61
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- International journal of food sciences and nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 20465434
- Full Text :
- https://doi.org/10.3109/09637486.2010.487480